Evidence map›Paper›PMID 30144648›Full record

ArticleNeurobiology of aging2018

Stress-induced corticosterone secretion covaries with working memory in aging.

Joseph A McQuail, Eric G Krause, Barry Setlow, Deborah A Scheuer, Jennifer L Bizon

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Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph A McQuailDepartment of Neuroscience, University of Florida, Gainesville, FL, USA. Electronic address: jmcquail@ufl.edu.
Eric G KrauseDepartment of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
Barry SetlowDepartment of Neuroscience, University of Florida, Gainesville, FL, USA; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Deborah A ScheuerDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA.
Jennifer L BizonDepartment of Neuroscience, University of Florida, Gainesville, FL, USA; Department of Psychiatry, University of Florida, Gainesville, FL, USA. Electronic address: bizonj@ufl.edu.

Funding

Neural Mechanisms of Cognitive Decline in AgingR01AG029421 · NIA · UNIVERSITY OF FLORIDA · PI BIZON, JENNIFER LYNN · 2007 to 2018
$3.1M
Molecular and physiological determinants of age-related working memory declineF32AG051371 · NIA · UNIVERSITY OF FLORIDA · PI MCQUAIL, JOSEPH ALOYSIUS · 2015 to 2017
$173k
NIA NIH HHS F32 AG051371NIA NIH HHS R01 AG029421
6 · The paper itself

Abstract

A substantial literature details the relationship between age-related changes to the hypothalamic-pituitary-adrenal axis and deterioration of mnemonic functions that depend on the hippocampus. The relationship between adrenocortical status and other forms of memory that depend on the prefrontal cortex is less well understood in the context of advanced age. Here, we characterized performance of young adult and aged F344 rats on a prefrontal cortex-dependent working memory task and subsequently measured corticosterone (CORT) levels over the diurnal cycle and during exposure to an acute stressor. Our analyses revealed that aged rats with better working memory mounted a greater CORT response during acute stress exposure than either young adults or age-matched rats with impaired working memory. We also observed that age-related elevation of basal CORT levels is not associated with working memory performance. Jointly, these data reveal that the hypothalamic-pituitary-adrenal axis-mediated response to acute stress is positively associated with working memory in aging.

Indexed as

AgingAnimalsChoice BehaviorCorticosteroneHypothalamo-Hypophyseal SystemMaleMemory, Short-TermPituitary-Adrenal SystemPrefrontal CortexRats, Inbred F344Restraint, PhysicalStress, PsychologicalCorticosteroneCircadianCorticosteroneGlucocorticoidsHypothalamic-pituitary-adrenal axisNormal agingPrefrontal cortexStressWorking memory

Identifiers

PMID30144648
PMCPMC6162104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.