Evidence map›Paper›PMID 30144522›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2019

The Gut Microbiome in Pancreatic Disease.

Venkata S Akshintala, Rupjyoti Talukdar, Vikesh K Singh, Michael Goggins

Abstract readReview
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Frontiers in endocrinology · 2026
    Article
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  15. Acute pancreatitis: Translating early mechanisms to bedside management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Venkata S AkshintalaDivision of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, Maryland.
Rupjyoti TalukdarDepartment of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India; Wellcome DBT Laboratories, Asian Healthcare Foundation, Hyderabad, India.
Vikesh K SinghDivision of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, Maryland.
Michael GogginsDivision of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, Maryland; Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland; Department of Oncology, Johns Hopkins Medical Institution, Baltimore, Maryland; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institution, Baltimore, Maryland. Electronic address: mgoggins@jhmi.edu.

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6M
Using markers to improve pancreatic cancer screening and surveillance: a multi-center studyU01CA210170 · NCI · JOHNS HOPKINS UNIVERSITY · PI Michael G. Goggins · 2016 to 2026
$9.3M
Using Markers to Improve Pancreatic Cancer ScreeningR01CA176828 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2013 to 2024
$4.1M
NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA176828NCI NIH HHS U01 CA210170
6 · The paper itself

Abstract

The gut microbiome increasingly is recognized for its role in human health and disease. Initial evidence has indicated that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate chronic proinflammatory changes in the pancreas. Further mechanistic and epidemiologic studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value.

Indexed as

Gastrointestinal MicrobiomeHost Microbial InteractionsDysbiosisGastrointestinal TractHumansPancreatic DiseasesDysbiosisIntratumoral BacteriaMicrobiomePancreatic CancerPancreatitisProbiotics

Identifiers

PMID30144522
PMCPMC6314887

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.