ArticleDevelopmental biology2018
A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Dynamic and non-uniform expression of key transcription factors provides insights into the emergence of neural crest cells at the neural plate border.Development (Cambridge, England) · 2026Article
- Wdr5 and Myc cooperate to regulate formation of neural crest stem cells.Development (Cambridge, England) · 2026Article
- Neanderthal-derived variants increase SOX9 enhancer activity in craniofacial progenitors that shape jaw development.Development (Cambridge, England) · 2025Article
- Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus.PLoS biology · 2025Article
- Shared features of blastula and neural crest stem cells evolved at the base of vertebrates.Nature ecology & evolution · 2024Article
- SoxB1 transcription factors are essential for initiating and maintaining neural plate border gene expression.Development (Cambridge, England) · 2024Article
- Characterization of Schistosome Sox Genes and Identification of a Flatworm Class of Sox Regulators.Pathogens (Basel, Switzerland) · 2023Article
- The developmental and evolutionary origins of cellular pluripotency in the vertebrate neural crest.Seminars in cell & developmental biology · 2023Review
- Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border.Frontiers in cell and developmental biology · 2022Article
- Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development.Frontiers in physiology · 2020Review
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- The origin and evolution of vertebrate neural crest cells.Open biology · 2020Review
- PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.Development (Cambridge, England) · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The neural crest is a stem cell population unique to vertebrate embryos that gives rise to derivatives from multiple embryonic germ layers. The molecular underpinnings of potency that govern neural crest potential are highly conserved with that of pluripotent blastula stem cells, suggesting that neural crest cells may have evolved through retention of aspects of the pluripotency gene regulatory network (GRN). A striking difference in the regulatory factors utilized in pluripotent blastula cells and neural crest cells is the deployment of different sub-families of Sox transcription factors; SoxB1 factors play central roles in the pluripotency of naïve blastula and ES cells, whereas neural crest cells require SoxE function. Here we explore the shared and distinct activities of these factors to shed light on the role that this molecular hand-off of Sox factor activity plays in the genesis of neural crest and the lineages derived from it. Our findings provide evidence that SoxB1 and SoxE factors have both overlapping and distinct activities in regulating pluripotency and lineage restriction in the embryo. We hypothesize that SoxE factors may transiently replace SoxB1 factors to control pluripotency in neural crest cells, and then poise these cells to contribute to glial, chondrogenic and melanocyte lineages at stages when SoxB1 factors promote neuronal progenitor formation.
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