Evidence map›Paper›PMID 30144380›Full record

Trial reportJournal of diabetes investigation2019

Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A randomized trial.

Felix Aberer, Julia K Mader, Julia Holzgruber, Christian Trummer, Verena Schwetz, Marlene Pandis, Peter N Pferschy, Hildegard Greinix, Norbert J Tripolt, Thomas R Pieber and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Pooled it
  2. Trial
  3. Review
  4. Stem cell transplant and graft versus host disease: designing and implementing a steroid-induced hyperglycemia tool kit.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Felix AbererDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Julia K MaderDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Julia HolzgruberDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Christian TrummerDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Verena SchwetzDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Marlene PandisDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Peter N PferschyDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Hildegard GreinixDivision of Hematology, Medical University of Graz, Graz, Austria.
Norbert J TripoltDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Thomas R PieberDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Armin ZebischDivision of Hematology, Medical University of Graz, Graz, Austria.
Heinz SillDivision of Hematology, Medical University of Graz, Graz, Austria.
Albert WölflerDivision of Hematology, Medical University of Graz, Graz, Austria.
Harald SourijDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steroid-induced hyperglycemia (SIHG) has shown to independently increase the risk for mortality in patients with acute graft-versus-host disease, and it is still unclear whether SIHG might be a modifiable risk factor. Therefore, a feasibility trial was carried out aiming to evaluate the performance of a standardized decision support system (GlucoTab [GT]) for insulin therapy in patients with SIHG. A total of 10 hyperglycemic acute graft-versus-host disease patients were included and treated either with GT or standard of care during hospitalization. Follow-up duration was 6 months. Comparing the GT versus standard of care group, 364 versus 1,020 glucose readings were available during a median of 41 days (interquartile range [IQR] 22-89) and 101 days (IQR 55-147) of hospitalization. The median overall glucose levels were 151 mg/dL (123-192) versus 162 mg/dL (IQR 138-193) for GT and standard of care, respectively (P < 0.001); hypoglycemia rates were comparably low. Treatment of SIHG with an algorithm-based system for subcutaneous insulin was feasible and safe.

Indexed as

Acute DiseaseBiomarkersBlood GlucoseFeasibility StudiesFemaleFollow-Up StudiesGlycated HemoglobinGraft vs Host DiseaseHumansHyperglycemiaHypoglycemic AgentsInsulinMaleMiddle AgedPilot ProjectsPrognosisBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulinSteroidsDecision support systemFeasibility trialSteroid-induced hyperglycemia

Identifiers

PMID30144380
PMCPMC6400241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.