Evidence map›Paper›PMID 30144277›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2019

Early or late pregnancy loss and development of clinical cardiovascular disease risk factors: a prospective cohort study.

J Horn, L J Tanz, J J Stuart, A R Markovitz, G Skurnik, E B Rimm, S A Missmer, J W Rich-Edwards

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

J HornDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
L J TanzDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J J StuartDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
A R MarkovitzDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
G SkurnikDivision of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
E B RimmDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
S A MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J W Rich-EdwardsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USLevanger Hospital · NO

Funding

Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
Preterm delivery and risk of maternal cardiovascular disease in the Nurses' Health Study IIF31HL131222 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TANZ, LAUREN · 2016 to 2018
$83k
American Heart Association 16PRE29690006National Heart, Lung, and Blood Institute T32HL098048National Institutes of Health UM1CA176726NCI NIH HHS UM1 CA176726NHLBI NIH HHS F31 HL131222NHLBI NIH HHS T32 HL098048Research Council of Norway 231149/F20Ruth L. Kirschstein National Research Service Award NHLBI F31 HL131222
6 · The paper itself

Abstract

objectiveTo assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors.

designProspective cohort study. SETTING AND POPULATION: Nurses' Health Study II.

methodsMultivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome and hypertension, type 2 diabetes, and hypercholesterolemia.

main outcome measuresHypertension, type 2 diabetes, and hypercholesterolemia.

resultsCompared to women who reported a singleton live first birth, women with early spontaneous abortion (<12 weeks) had a greater rate of type 2 diabetes (HR: 1.20; 95% CI: 1.07-1.34) and hypercholesterolemia (HR: 1.06; 95% CI: 1.02-1.10), and a marginally increased rate of hypertension (HR: 1.05, 95% CI: 1.00-1.11). Late spontaneous abortion (12-19 weeks) was associated with an increased rate of type 2 diabetes (HR: 1.38; 95% CI: 1.14-1.65), hypercholesterolemia (HR: 1.11; 95% CI: 1.03-1.19), and hypertension (HR: 1.15; 95% CI: 1.05-1.25). The rates of type 2 diabetes (HR: 1.45; 95% CI: 1.13-1.87) and hypertension (HR: 1.15; 95% CI: 1.01-1.30) were higher in women who delivered stillbirth. In contrast, women whose first pregnancy ended in an induced abortion had lower rates of hypertension (HR: 0.87; 95% CI: 0.84-0.91) and type 2 diabetes (HR: 0.89; 95% CI: 0.79-0.99) than women with a singleton live birth.

conclusionsSeveral types of pregnancy loss were associated with an increased rate of hypertension, type 2 diabetes, and hypercholesterolemia, which may provide novel insight into the pathways through which pregnancy outcomes and CVD are linked. TWEETABLE ABSTRACT: Pregnancy loss is associated with later maternal risk of hypertension, type 2 diabetes, and hypercholesterolemia.

Indexed as

Abortion, InducedAbortion, SpontaneousAdultConfidence IntervalsDiabetes Mellitus, Type 2FemaleGestational AgeHumansHypercholesterolemiaHypertensionPregnancyPregnancy OutcomeProportional Hazards ModelsProspective StudiesRisk FactorsStillbirthCardiovascular diseasesdiabetes mellitushypercholesterolemiahypertensionpregnancy lossrisk factorsspontaneous abortionstillbirthwomen's health

Identifiers

PMID30144277
PMCPMC6294683
OpenAlexW2888076620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.