Evidence map›Paper›PMID 30144156›Full record

ArticleFundamental & clinical pharmacology2019

Interleukin-10 negatively modulates extracellular signal-regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion.

Alecsander F Bressan, Gisele A Fonseca, Rita C Tostes, R Clinton Webb, Victor Vitorino Lima, Fernanda Regina Giachini

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fundamental & clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alecsander F BressanInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjão 6390, Barra do Garças, Mato Grosso, 78600-000, Brazil.ORCID http://orcid.org/0000-0001-7629-8972
Gisele A FonsecaDepartment of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Goiás (UFG), Av. Esperança, sem número, Campus Samambaia, Goiânia-Goiás, 74690-900, Brazil.
Rita C TostesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, N3900, Monte Alegre, Ribeirão Preto-São Paulo, 14049-900, Brazil.
R Clinton WebbDepartment of Physiology, Augusta University, 1120 15th Street, CA3126, Augusta-Georgia, 30912, USA.
Victor Vitorino LimaInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjão 6390, Barra do Garças, Mato Grosso, 78600-000, Brazil.
Fernanda Regina GiachiniInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Av. Valdon Varjão 6390, Barra do Garças, Mato Grosso, 78600-000, Brazil.
Universidade Federal de Mato Grosso · BRAugusta University · USUniversidade de São Paulo · BRUniversidade Federal de Goiás · BR

Funding

Toll-like receptor 9 activation by mitochondrial DNA causes vascular injury in hypertensionP01HL134604 · NHLBI · AUGUSTA UNIVERSITY · PI BRANDS, MICHAEL W. · 2017 to 2021
$9.4M
TNF-alpha: a key player in erectile (dys)functionR01DK083685 · NIDDK · AUGUSTA UNIVERSITY · PI WEBB, R CLINTON · 2009 to 2012
$1.4M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 471675/2013-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038009165/2013-48Fundação de Amparo à Pesquisa do Estado de Mato Grosso 151371/2014Fundação de Amparo à Pesquisa do Estado de São Paulo 2010/52214-6National Institutes of Health DK83685National Institutes of Health HL134604NHLBI NIH HHS P01 HL134604NIDDK NIH HHS R01 DK083685
6 · The paper itself

Abstract

The activation of extracellular signal-regulated kinase 1 and 2 (ERK 1/2) pathway promotes increased vascular contractility in angiotensin II (Ang II)-induced hypertensive mice. Interleukin-10 (IL-10) is an immune-regulatory cytokine with the ability to prevent vascular hypercontractility during hypertension. We hypothesized that IL-10 would downregulate vascular ERK 1/2 activation during Ang II-induced hypertension. Wild-type (WT) or IL-10 knockout (IL-10

Indexed as

Angiotensin IIAnimalsAortaBlotting, WesternDisease Models, AnimalFlavonoidsHypertensionInterleukin-10MaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneAngiotensin IIFlavonoidsInterleukin-10Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhenylephrinecytokineMAP kinasesmooth muscle cell and contraction

Identifiers

PMID30144156
PMCPMC6816245
OpenAlexW2888326758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.