ArticleAllergy2019
Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing.
Article in Allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review.Frontiers in immunology · 2022Pooled it
- Impact of COVID-19 pandemic on childhood asthma and wheezing disorders.World journal of pediatrics : WJP · 2025Article
- Pre-Existing Allergies Patients with Higher Viral Load and Longer Recovery Days Infected by SARS-CoV-2 Omicron BA.2 in Shanghai, China, 2022.Journal of asthma and allergy · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Heterogeneous associations of polyomaviruses and herpesviruses with allergy-related phenotypes in childhood.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
- SARS coronavirus 2: from genome to infectome.Respiratory research · 2020Review
- Eleven faces of coronavirus disease 2019.Allergy · 2020Article
- Role of viruses in asthma.Seminars in immunopathology · 2020Review
- Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.The journal of allergy and clinical immunology. In practice · 2020Article
- Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing.Allergy · 2019Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWheezing illnesses among young children are common and are a risk factor for asthma. However, determinants of childhood bronchial reactivity, a key feature of asthma, are largely unknown. The aim of this study was to determine how patient characteristics during the first severe virus-induced wheezing episode are associated with pulmonary function at preschool age.
methodsStudy consisted of 76 children presenting with their first wheezing episode at the ages of 3 to 23 months. At study entry, viral etiology, rhinovirus genome load, atopic and clinical characteristics, and standardized questionnaire were analyzed. At 4-year follow-up visit, impulse oscillometry with exercise challenge was performed.
resultsAt study entry, the mean age of the children was 12 months (SD 6.0), 57 (75%) were rhinovirus positive, and 22 (30%) were sensitized. At follow-up visit four years later, the mean age of the children was 60 months (SD 7.9) and 37 (49%) were using asthma medication regularly (discontinued before testing in 25 [68%] children). Bronchial reactivity (≥35% change in mean crude values of resistance) after exercise challenge or bronchodilation was present in nine (12%) children. Children with atopic sensitization at the time of the first wheezing episode were more often likely to develop bronchial reactivity (odds ratio 8.8, P = 0.03) than the children without sensitization. No other significant associations were found.
conclusionsAtopic sensitization at the time of the first severe wheezing episode is an important early risk factor for increased bronchial reactivity at preschool age.
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