ReviewDevelopmental psychobiology2018
Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment.
Review in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- A Systematic Review and Meta-analysis of Parental Depression, Antidepressant Usage, Antisocial Personality Disorder, and Stress and Anxiety as Risk Factors for Attention-Deficit/Hyperactivity Disorder (ADHD) in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- The impact of childhood trauma on psychological interventions for depression during pregnancy and postpartum: a systematic review.Archives of women's mental health · 2021Pooled it
- Intergenerational continuity of parent-child separation: implications for child allergies and total IgE in China.Pediatric research · 2026Article
- Intergenerational Effects of Maternal Stressful Life Events Before Pregnancy on Offspring Growth: A Lifecourse Approach from a Prospective Cohort.International journal of women's health · 2026Article
- Posttraumatic stress disorder in the preconception period: an open pilot feasibility study.Maternal health, neonatology and perinatology · 2025Article
- Predicting 5-year-olds mental health at birth: development and internal validation of a multivariable model using the prospective ELFE birth cohort.European child & adolescent psychiatry · 2025Article
- Parental preconceptual α-cypermethrin exposure alters embryonic brain transcriptomics in mice: Implications for autism spectrum disorder and stress vulnerability.Neurotoxicology · 2025Article
- The PREGO Study: A Preconception Cohort to Better Understand Perinatal Mental Health.International journal of psychology : Journal international de psychologie · 2025Article
- Delineating the Transmission of Subthreshold Psychosis Symptoms Across Generations: The Philadelphia Family Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Association of placental mitochondrial DNA mutations on infant negative affectivity: modifying effects of maternal lifetime stress and infant sex.Biology of sex differences · 2025Article
- Maternal childhood adversity accelerates epigenetic aging of children.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Intergenerational Effects of Stress - A Focus on Learning and Memory.Current topics in behavioral neurosciences · 2025Review
- Developmental cascades from maternal preconception stress to child behavior problems: Testing multilevel preconception, prenatal, and postnatal influences.Developmental psychology · 2024Article
- Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress.Applied biochemistry and biotechnology · 2024Article
- Parental Preconception Posttraumatic Stress Symptoms and Maternal Prenatal Inflammation Prospectively Predict Shorter Telomere Length in Children.Psychosomatic medicine · 2024Article
- Leveraging the interpersonal context of child development to promote family resilience: A universal prevention approach from preconception through early childhood.Mental health & prevention · 2024Article
- Experience of discrimination reported during pregnancy and infant's emerging effortful control.Developmental psychobiology · 2024Article
- Intergenerational transmission of stress: Multi-domain stressors from maternal childhood and pregnancy predict children's mental health in a racially and socioeconomically diverse, multi-site cohort.Social psychiatry and psychiatric epidemiology · 2023Article
- Intergenerational effects of maternal lifetime stressor exposure on offspring telomere length in Black and White women.Psychological medicine · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The concept of the developmental origins of health and disease via prenatal programming has informed many etiologic models of health and development. Extensive experimental research in non-human animal models has revealed the impact of in utero exposure to stress on fetal development and neurodevelopment later in life. Stress exposure, however, is unlikely to occur de novo following conception, and pregnancy health is not independent of the health of the system prior to conception. For these reasons, the preconception period is emerging as an important new focus for research on adverse birth outcomes and offspring neurodevelopment. In this review, we summarize the existing evidence for the role of preconception stress exposure on pregnancy health and offspring neurodevelopment across species and discuss the implications of this model for addressing health disparities in obstetrics and offspring outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.