Evidence map›Paper›PMID 30143940›Full record

ArticleEndocrine2018

Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia.

Danijela Radojkovic, Milica Pesic, Milan Radojkovic, Dragan Dimic, Marija Vukelic Nikolic, Tatjana Jevtovic Stoimenov, Sasa Radenkovic, Milena Velojic Golubovic, Tatjana Radjenovic Petkovic, Slobodan Antic

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In one paragraph

Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Current Insights in Prolactin Signaling and Ovulatory Function.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Danijela RadojkovicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia. dr.danijela3@gmail.com.
Milica PesicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Milan RadojkovicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Dragan DimicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Marija Vukelic NikolicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Tatjana Jevtovic StoimenovMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Sasa RadenkovicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Milena Velojic GolubovicMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
Tatjana Radjenovic PetkovicCenter for Medical Biochemistry, Clinical Center, Nis, Blvd.dr Zoran Djindjic 48, 18000, Nis, Serbia.
Slobodan AnticMedical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.
University of Nis · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimHyperprolactinaemia in pregnancy leads to mild and reversible changes in the maternal skeletal system, and medicamentous hyperprolactinemia causes more detrimental effects. We conducted an experimental study to evaluate differences between Prlr gene expression in the duodenum, vertebrae and kidneys during physiological and medicamentous hyperprolactinaemia, which could influence calcium homeostasis.

methodsExperimental animals (18 weeks old, Wistar female rats) were divided as follows: group P (nine rats that were 3 weeks pregnant), group M (ten rats that were intramuscularly administrated sulpiride (10 mg/kg) twice daily for 3 weeks), and the control group (C, ten age-matched nulliparous rats, 18-week-old). Laboratory investigations included measurements of serum ionized calcium, phosphorus, urinary calcium and phosphorus excretion, osteocalcin (OC), serum procollagen type 1 N-terminal propeptide (P1NP), vitamin D, parathyroid hormone (PTH) and prolactin (PRL). Relative quantification of gene expression for prolactin receptors in the duodenum, vertebrae and kidneys was determined using real-time PCR.

resultsExpression of the Prlr gene was significantly higher in the duodenum (p < 0.001) and lower in vertebrae (p < 0.001) and kidneys (p < 0.01) in rats with physiological hyperprolactinaemia (PHP) than in the control group. Significantly lower Prlr expression in the duodenum was verified (p < 0.001), along with increased Prlr gene expression in vertebrae (p < 0.001) and kidneys (p < 0.01), in rats with medicamentous hyperprolactinaemia (MHP) than in the C group.

conclusionsDownregulation of Prlr gene expression in the duodenum may explain the diminished intestinal calcium absorption in medicamentous hyperprolactinaemia. Prolactin takes calcium from the skeletal system following increased Prlr gene expression in the vertebrae to maintain calcium homeostasis, which increases the harmful effect on bone metabolism compared to that of physiological hyperprolactinaemia.

Indexed as

AnimalsBone and BonesCalciumDuodenumFemaleHyperprolactinemiaKidneyOsteocalcinParathyroid HormonePhosphorusPregnancyRatsRats, WistarReceptors, ProlactinSulpirideCalciumOsteocalcinParathyroid HormonePhosphorusReceptors, ProlactinSulpirideCalcium homeostasisDuodenumKidneyProlactin receptorsSkeletal system

Identifiers

PMID30143940
OpenAlexW2888269222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.