Evidence map›Paper›PMID 30143887›Full record

ArticleEuropean child & adolescent psychiatry2019

Blood CRP levels are elevated in children and adolescents with functional neurological symptom disorder.

Kasia Kozlowska, Jason Chung, Bronya Cruickshank, Loyola McLean, Stephen Scher, Russell C Dale, Shekeeb S Mohammad, Davinder Singh-Grewal, Mukesh Yajaman Prabhuswamy, Ellis Patrick

Abstract read
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In one paragraph

Article in European child & adolescent psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  12. Pediatric investigation · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kasia KozlowskaDepartment Psychological Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia. kkoz6421@uni.sydney.edu.au.ORCID http://orcid.org/0000-0002-9578-0753
Jason ChungDepartment of Clinical Biochemistry, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.
Bronya CruickshankDepartment Psychological Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.
Loyola McLeanWestmead Psychotherapy Program for Complex Traumatic Disorders, Western Sydney Local Health District, Building 112, Cumberland Hospital Campus, Parramatta BC, Locked Bag 7118, Parramatta, NSW, 2124, Australia.
Stephen ScherDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Russell C DaleDiscipline of Child and Adolescent Health, University of Sydney Medical School, Sydney, NSW, Australia.
Shekeeb S MohammadDiscipline of Child and Adolescent Health, University of Sydney Medical School, Sydney, NSW, Australia.
Davinder Singh-GrewalDiscipline of Child and Adolescent Health, University of Sydney Medical School, Sydney, NSW, Australia.
Mukesh Yajaman PrabhuswamyDepartment Psychological Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.
Ellis PatrickSchool of Mathematics and Statistics, University of Sydney, F07 - Carslaw Building, Sydney, NSW, 2006, Australia.
The University of Sydney · AUCamden and Campbelltown Hospitals · AUChildren's Hospital at Westmead · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is accumulating evidence that patients with functional neurological symptom disorder (FND) show activation of multiple components of the stress system-the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and brain regions involved in arousal- and emotion-processing. This study aims to examine whether the immune-inflammatory component of the stress system is also activated. C-reactive protein (CRP) blood titre levels were measured in 79 children and adolescents with FND. CRP values ≥ 2 mg/L suggest low-grade inflammation. CRP values > 10 mg/L suggest a disease process. Sixty-six percent of subjects (n = 52) had CRP titres ≥ 2 mg/L. The upward shift in the distribution of CRP levels suggested low-grade inflammation (median CRP concentration was 4.60 mg/L, with 75th and 90th percentiles of 6.1 and 10.3 mg/L, respectively). Elevated CRP titres were not explained by sex, pubertal status, BMI, or medical factors. Confounder analyses suggested that history of maltreatment (χ

Indexed as

AdolescentAnxietyBiomarkersBrainChildC-Reactive ProteinFemaleHumansHypothalamo-Hypophyseal SystemMaleNervous System DiseasesNeurodevelopmental DisordersPituitary-Adrenal SystemSelf ReportBiomarkersC-Reactive ProteinConversion disorderDissociationFunctional neurological symptomsNeuroinflammationNon-epileptic seizures

Identifiers

PMID30143887
OpenAlexW2888050192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.