ArticleArchives of toxicology2018
Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices.
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Article in Archives of toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- S-Ketamine Preserves Oxidative Metabolism and Reduces Metabolic Stress During Neuronal Hyperexcitability.International journal of molecular sciences · 2026Article
- Propofol regulates SLC6A2 expression via NAT10-mediated ac4C modification to modulate excessive mitophagy and hippocampal neuron dysfunction in aged postoperative cognitive dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Intermittent Propofol Exposure Induces Neurodevelopmental Alterations in Human Brain Organoids.Cellular and molecular neurobiology · 2026Article
- Clinical Electroencephalography for Anesthesiologists and Intensivists: Part 2-Physiologic Signatures and Active Management.Anesthesiology · 2025Review
- Short- and long-term effects of single neonatal exposure to propofol anesthesia on cognitive function.The Journal of international medical research · 2025Article
- Metabolic Adaptation in Epilepsy: From Acute Response to Chronic Impairment.International journal of molecular sciences · 2024Article
- Isoflurane lowers the cerebral metabolic rate of oxygen and prevents hypoxia during cortical spreading depolarizationJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Multidisciplinary Approach to Sedation and Early Mobility of Intubated Critically Ill Neurologic Patients Improves Mobility at Discharge.The Neurohospitalist · 2023Article
- Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms.Cell biology and toxicology · 2023Article
- Modulatory dynamics mark the transition between anesthetic states of unconsciousness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- BIS feedback closed-loop target-controlled infusion of propofol or etomidate in elderly patients with spinal surgery.American journal of translational research · 2023Article
- Protective down-regulated states in the human brain: A possible lesson from COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Propofol produces neurotoxicity by inducing mitochondrial apoptosis.Experimental and therapeutic medicine · 2022Article
- Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway.BMC pharmacology & toxicology · 2022Article
- Sevoflurane Effects on Neuronal Energy Metabolism Correlate with Activity States While Mitochondrial Function Remains Intact.International journal of molecular sciences · 2022Article
- Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress.International journal of molecular sciences · 2022Article
- Mitigation of perioperative neurocognitive disorders: A holistic approach.Frontiers in aging neuroscience · 2022Review
- An Integrative Bioinformatics Analysis of the Potential Mechanisms Involved in Propofol Affecting Hippocampal Neuronal Cells.Computational intelligence and neuroscience · 2022Article
- Propofol effects in rodent models of traumatic brain injury: a systematic review.Asian biomedicine : research, reviews and news · 2021Article
- Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Nikolaus BerndtInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Jörg RösnerNeuroscience Research Center, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Rizwan Ul HaqNeuroscience Research Center, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Oliver KannInstitute of Physiology and Pathophysiology, University of Heidelberg, 69120, Heidelberg, Germany.
Richard KovácsInstitute for Neurophysiology, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Hermann-Georg HolzhütterInstitute of Biochemistry, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Claudia SpiesDepartment of Anesthesiology and Intensive Care, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Agustin LiottaNeuroscience Research Center, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany. agustin.liotta@charite.de.
Charité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEHumboldt-Universität zu Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEHeidelberg University · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol is the most frequently used intravenous anesthetic for induction and maintenance of anesthesia. Propofol acts first and formost as a GABA
Indexed as
Adenosine TriphosphateAnesthetics, IntravenousAnimalsCA3 Region, HippocampalElectron Transport Complex IIFlavin-Adenine DinucleotideHippocampusMaleMitochondriaNeurotoxicity SyndromesOrgan Culture TechniquesOxygen ConsumptionPropofolRats, WistarSynaptic TransmissionAdenosine TriphosphateAnesthetics, IntravenousElectron Transport Complex IIFlavin-Adenine DinucleotidePropofolAnesthesiaComplex IIGamma oscillationHippocampusMitochondriaPropofol
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