ArticleScientific reports2018
Bovine telomere dynamics and the association between telomere length and productive lifespan.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Telomere Length in Neonatal Dairy Calves in Relation to Lifetime Parameters.Animals : an open access journal from MDPI · 2025Article
- Article
- Telomere Dynamics in Livestock.Biology · 2023Review
- Article
- Article
- Comparison of Telomere Length in Age-Matched Primiparous and Multiparous Brahman Cows.Animals : an open access journal from MDPI · 2023Article
- Early-life telomere length predicts life-history strategy and reproductive senescence in a threatened wild songbird.Molecular ecology · 2023Article
- Prenatal environment impacts telomere length in newborn dairy heifers.Scientific reports · 2023Article
- Characterization of telomere length in Agerolese cattle breed, correlating blood and milk samples.Animal genetics · 2022Article
- How much energetic trade-offs limit selection? Insights from livestock and related laboratory model species.Evolutionary applications · 2021Article
- Heritable variation in telomere length predicts mortality in Soay sheep.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle.Scientific reports · 2021Article
- Analysis of Longevity Traits in Holstein Cattle: A Review.Frontiers in genetics · 2021Review
- A short life on the farm: aging and longevity in agricultural, large-bodied mammals.GeroScience · 2020Review
- The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness.Frontiers in genetics · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Average telomere length (TL) in blood cells has been shown to decline with age in a range of vertebrate species, and there is evidence that TL is a heritable trait associated with late-life health and mortality in humans. In non-human mammals, few studies to date have examined lifelong telomere dynamics and no study has estimated the heritability of TL, despite these being important steps towards assessing the potential of TL as a biomarker of productive lifespan and health in livestock species. Here we measured relative leukocyte TL (RLTL) in 1,328 samples from 308 Holstein Friesian dairy cows and in 284 samples from 38 female calves. We found that RLTL declines after birth but remains relatively stable in adult life. We also calculated the first heritability estimates of RLTL in a livestock species which were 0.38 (SE = 0.03) and 0.32 (SE = 0.08) for the cow and the calf dataset, respectively. RLTL measured at the ages of one and five years were positively correlated with productive lifespan (p < 0.05). We conclude that bovine RLTL is a heritable trait, and its association with productive lifespan may be used in breeding programmes aiming to enhance cow longevity.
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