Evidence map›Paper›PMID 30143749›Full record

ReviewNature reviews. Microbiology2018

Molecular mechanisms of viral oncogenesis in humans.

Nathan A Krump, Jianxin You

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 1 synthesis or guideline pooled it, 287 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
  6. Review
  7. Absence of DNA viruses in ameloblastomas.European journal of oral sciences · 2026
    Article
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  9. Review
  10. Review
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  12. Article
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  17. Efficacy of Immune Checkpoint Inhibitors and Oncoviruses in Solid Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
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  19. Review
  20. Review

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nathan A KrumpDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jianxin YouDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jianyou@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Merkel cell polyomavirus infection, host response, and viral oncogenic mechanismR01CA187718 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Jianxin You · 2015 to 2026
$3.7M
Mechanism of Brd4-mediated papillomavirus host interactionsR01CA142723 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YOU, JIANXIN · 2010 to 2014
$1.8M
Chromatin structure maintenance and cancerR01CA148768 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YOU, JIANXIN · 2010 to 2014
$1.6M
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA142723NCI NIH HHS R01 CA148768NCI NIH HHS R01 CA187718
6 · The paper itself

Abstract

Viral infection is a major contributor to the global cancer burden. Recent advances have revealed that seven known oncogenic viruses promote tumorigenesis through shared host cell targets and pathways. A comprehensive understanding of the principles of viral oncogenesis may enable the identification of unknown infectious aetiologies of cancer and the development of therapeutic or preventive strategies for virus-associated cancers. In this Review, we discuss the molecular mechanisms of viral oncogenesis in humans. We highlight recent advances in understanding how viral manipulation of host cellular signalling, DNA damage responses, immunity and microRNA targets promotes the initiation and development of cancer.

Indexed as

CarcinogenesisHost-Pathogen InteractionsDNA DamageHumansImmunityMicroRNAsNeoplasmsOncogenic VirusesSignal TransductionTumor Virus InfectionsMicroRNAs

Identifiers

PMID30143749
PMCPMC6336458
OpenAlexW2888554793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.