ArticleScientific reports2018
Intra-individual alterations of serum markers routinely used in forensic pathology depending on increasing post-mortem interval.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Urea nitrogen levels in postmortem serum, vitreous humor, and cerebrospinal fluid.International journal of legal medicine · 2026Article
- Exploring the post-mortem interval through blood biochemistry: a preliminary case series study and review of the literature.International journal of legal medicine · 2025Review
- Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.International journal of legal medicine · 2025Article
- Variance in intraindividual stability of vitreous humor for thanatochemistry.International journal of legal medicine · 2025Article
- Fatal anaphylactic shock due to hymenoptera venom in a farmer suffering from indolent systemic mastocytosis. The comparative diagnostic relevance of perimortem serum tryptase levels.International journal of legal medicine · 2025Article
- Advances and Challenges in Traumatic Brain Injury from a Forensic Perspective.Current neuropharmacology · 2025Review
- Evaluation of the efficacy of cephalosporin antibiotics sold in Kano, Nigeria, against clinical bacterial isolates.Access microbiology · 2025Article
- Development and validation of a rapid LC-MS/MS method for the detection of 182 novel psychoactive substances in whole blood.Drug testing and analysis · 2022Article
- Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart.Cardiovascular research · 2022Article
- The Importance of BHB Testing on the Post-Mortem Diagnosis of Ketoacidosis.Biomolecules · 2021Article
- GFAP positivity in neurons following traumatic brain injuries.International journal of legal medicine · 2021Article
- Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid.Biomolecules · 2021Article
- Screening for Fatal Traumatic Brain Injuries in Cerebrospinal Fluid Using Blood-Validated CK and CK-MB Immunoassays.Biomolecules · 2021Article
- Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®).Legal medicine (Tokyo, Japan) · 2021Article
- Molecular profiling of the intestinal mucosa and immune cells of the colon by multi-parametric histological techniques.Scientific reports · 2021Article
- Diagnostic Application of Postmortem Cardiac Troponin I Pericardial Fluid/Serum Ratio in Sudden Cardiac Death.Diagnostics (Basel, Switzerland) · 2021Article
- CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.Scientific reports · 2021Article
- Circular RNAs in Sudden Cardiac Death Related Diseases: Novel Biomarker for Clinical and Forensic Diagnosis.Molecules (Basel, Switzerland) · 2021Review
- Cephalosporins' Cross-Reactivity and the High Degree of Required Knowledge. Case Report and Review of the Literature.Antibiotics (Basel, Switzerland) · 2020Article
- Combined determination of B-type natriuretic peptide and high-sensitivity troponin I in the postmortem diagnosis of cardiac disease.Forensic science, medicine, and pathology · 2019Article
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8 authors.
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Abstract
Post-mortem biochemistry of serum markers has been the subject of numerous studies, but in-situ marker stability after death has not been sufficiently evaluated yet. Such laboratory analyses are especially necessary in the cases of functional deaths without morphological evidence of the death causes and also in cardiac death cases with only very short survival times. The aim of the study was to determine the post-mortem stability of commonly-used serum markers at predefined time points. In 20 cases, peripheral venous samples were taken starting immediately after circulatory arrest and ending 48 hours after death. Serum creatinine, urea, 3-β-hydroxybutyrate, tryptase, myoglobin, troponin T, creatin kinase and creatin kinase-MB have been included. For all markers, we observed increasing marker levels for longer post-mortem intervals. Significant marker level changes began two hours after death. Excessive increases were observed for cardiac and muscle markers. Marker levels showed high intra-assay precision. Furthermore, the markers were robust enough to withstand freeze-thaw cycles. Potential contamination of arteriovenous blood did not influence the post-mortem marker levels. Post-mortem blood should be sampled as soon as possible, as increased post-mortem intervals may heavily change marker levels in-situ in individual cases, whereas the markers are mostly unaffected by laboratory conditions.
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