ArticleScientific reports2018
Assessment of the ability of open- and closed-loop cueing to improve turning and freezing in people with Parkinson's disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174948 (The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders: A Feasibility Study
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insights into Parkinson's Disease-Related Freezing of Gait Detection and Prediction Approaches: A Meta Analysis.Sensors (Basel, Switzerland) · 2024Pooled it
- Trial
- Integrating Eye Tracking and Inertial Sensing for Enhanced Freezing of Gait Detection in Parkinson's Disease.The European journal of neuroscience · 2026Article
- Freezing of gait and the effects of vibrotactile cueing in Parkinson's disease-a study protocol of a cross-sectional multimodal brain imaging approach in virtual walking scenarios.Frontiers in neuroscience · 2026Article
- The mechanism of external cueing interventions in improving freezing of gait in Parkinson's disease: an fNIRS study.Frontiers in aging neuroscience · 2026Article
- Digital Cueing With Laser Shoes Does Not Improve Walking in Parkinson's Disease: Evidence Across Disease Severity and Freezing Status.Neurorehabilitation and neural repair · 2025Article
- Ankle Bracelet Laser as a Novel Portable Device to Improve Walking in Patients With Parkinsonism: Randomized Crossover Controlled Trial.JMIR rehabilitation and assistive technologies · 2025Article
- Personalized versus fixed tactile cueing in Parkinson's disease: Protocol for a randomized controlled trial on gait automaticity.PloS one · 2025Article
- Better Understanding Rehabilitation of Motor Symptoms: Insights from the Use of Wearables.Pragmatic and observational research · 2025Review
- Influence of strength and power training on the rate of force development, peak force and functional mobility in elderly people with Parkinson's disease: a randomized controlled trial.Frontiers in neurology · 2025Article
- Vibrotactile Foot Device for Freezing of Gait in Parkinson's Disease: A Pilot Study.Movement disorders clinical practice · 2024Article
- Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease.Brain sciences · 2024Article
- Beyond timing and step counting in 360° turning-in-place assessment: a scoping review.Biomedical engineering online · 2024Article
- Laser-light cueing shoes with integrated foot pressure and inertial sensing for investigating the impact of visual cueing on gait characteristics in Parkinson's disease individuals.Frontiers in bioengineering and biotechnology · 2024Article
- Gait-modifying effects of augmented-reality cueing in people with Parkinson's disease.Frontiers in neurology · 2024Article
- The effect of tactile cueing on dual task performance in Parkinson's disease. A systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2024Review
- Agreement between Optoelectronic System and Wearable Sensors for the Evaluation of Gait Spatiotemporal Parameters in Progressive Supranuclear Palsy.Sensors (Basel, Switzerland) · 2023Article
- Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson's disease.Biomedical engineering online · 2023Article
- Good vibrations: tactile cueing for freezing of gait in Parkinson's disease.Journal of neurology · 2023Article
- Adaptive cueing strategy for gait modification: A case study using auditory cues.Frontiers in neurorobotics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Turning impairments are common in Parkinson's disease (PD) and can elicit freezing of gait (FoG). Extensive examination of open-loop cueing interventions has demonstrated that they can ameliorate gait deficits in PD; less is known about efficacy to improve turning. Here, we investigate the immediate effectiveness of open- and closed-loop cueing in improving turning characteristics in people with PD. Twenty-five subjects with and 18 subjects without FoG participated in the study. Subjects turned in place for one minute under single- and dual-task for 3 randomized conditions: (i) Baseline; (ii) Turning to the beat of a metronome (open-loop); and (iii) Turning with phase-dependent tactile biofeedback (closed-loop). Objective measures of freezing, such as % time spent freezing and FoG-ratio, significantly improved when turning with both open-loop and closed-loop cueing compared to baseline. Dual-tasking did not worsen FoG in freezers, but significantly slowed down turns in both groups. Both cueing modalities significantly improved turning smoothness in both groups, but reduced turning velocity and number of turns compared to baseline. Both open and closed-loop cueing markedly improved turning in people with PD. These preliminary observations warrant further exploration of vibrotactile closed-loop cueing to improve mobility in everyday life.
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Registered trials
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