ArticleNature communications2018
Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
- Influence of the drone brood homogenate on the gut integrity and cellular immunity: A pilot study on pigs.Veterinarni medicina · 2026Article
- Nepenthes chitinase NkChit2b- 1 confers broad-spectrum resistance to chitin-containing pathogens and insects in plants.Advanced biotechnology · 2025Article
- Deciphering the universal role of gut microbiota in pollutant transformation.The ISME journal · 2025Review
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- A conserved bacterial genetic basis for commensal-host specificity.Science (New York, N.Y.) · 2024Article
- Microbiome analysis reveals the intestinal microbiota characteristics and potential impact of Procambarus clarkii.Applied microbiology and biotechnology · 2024Article
- Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The gastric mucosa of Atlantic salmon (Salmo salar) is abundant in highly active chitinases.FEBS open bio · 2024Article
- Metagenome-assembled genomes of threeAccess microbiology · 2024Article
- Insights Into a Chitin Synthase of Kuruma Shrimp Penaeus japonicus and Its Role in Peritrophic Membrane and Cuticle Formation.Marine biotechnology (New York, N.Y.) · 2023Article
- Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis.Microbiome · 2023Article
- Repetitive and zonal expression profiles of absorption-related genes in the gastrointestinal tract of ascidian Ciona intestinalis type A.Cell and tissue research · 2023Article
- Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice.International journal of molecular sciences · 2023Article
- Gene family expansion and functional diversification of chitinase and chitin synthase genes in Atlantic salmon (Salmo salar).G3 (Bethesda, Md.) · 2023Article
- Unexpected Distribution of Chitin andBiomolecules · 2023Article
- Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments.EMBO reports · 2023Article
- The old friends hypothesis: evolution, immunoregulation and essential microbial inputs.Frontiers in allergy · 2023Review
- Identification of Chitin Allomorphs in Poorly Crystalline Samples Based on the Complexation with Ethylenediamine.Biomacromolecules · 2022Article
- The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development.The Journal of clinical investigation · 2022Article
- Uniaxial orientation of β-chitin nanofibres used as an organic framework in the scales of a hot vent snail.Journal of the Royal Society, Interface · 2022Article
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Authors and funding
14 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian gut microbiota are integral to host health. However, how this association began remains unclear. We show that in basal chordates the gut space is radially compartmentalized into a luminal part where food microbes pass and an almost axenic peripheral part, defined by membranous delamination of the gut epithelium. While this membrane, framed with chitin nanofibers, structurally resembles invertebrate peritrophic membranes, proteome supports its affinity to mammalian mucus layers, where gut microbiota colonize. In ray-finned fish, intestines harbor indigenous microbes, but chitinous membranes segregate these luminal microbes from the surrounding mucus layer. These data suggest that chitin-based barrier immunity is an ancient system, the loss of which, at least in mammals, provided mucus layers as a novel niche for microbial colonization. These findings provide a missing link for intestinal immune systems in animals, revealing disparate mucosal environment in model organisms and highlighting the loss of a proven system as innovation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.