Evidence map›Paper›PMID 30143580›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Arginine-deprivation-induced oxidative damage sterilizes

Sangeeta Tiwari, Andries J van Tonder, Catherine Vilchèze, Vitor Mendes, Sherine E Thomas, Adel Malek, Bing Chen, Mei Chen, John Kim, Tom L Blundell and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 116 citations in OpenAlex.

  1. L-cysteine inhibited the growth ofApplied and environmental microbiology · 2026
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  3. Induced alanine auxotrophy as a therapeutic strategy againstbioRxiv : the preprint server for biology · 2026
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  4. Usnic Acid Derivatives as Inhibitors ofInternational journal of molecular sciences · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Sangeeta TiwariDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; sangeeta.tiwari@einstein.yu.edu jacobsw@hhmi.org.
Andries J van TonderWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.ORCID 0000-0002-4380-5250
Catherine VilchèzeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Vitor MendesDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
Sherine E ThomasDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
Adel MalekDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bing ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Mei ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
John KimDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom.
Julian ParkhillWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Brian WeinrickDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-0880-4487
Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; sangeeta.tiwari@einstein.yu.edu jacobsw@hhmi.org.
Albert Einstein College of Medicine · USUniversity of Cambridge · GBWellcome Sanger Institute · GB

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI026170NIAID NIH HHS R37 AI026170Wellcome TrustWellcome Trust 098051
6 · The paper itself

Abstract

Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in vivo survival may exhibit powerful synergistic action. This study demonstrates that the de novo arginine biosynthetic pathway in

Indexed as

Oxidative StressAntioxidantsAntitubercular AgentsArginineDNA DamageDrug Resistance, BacterialFlow CytometryGene Expression ProfilingIn Vitro TechniquesMetabolic Networks and PathwaysMycobacterium tuberculosisReactive Oxygen SpeciesSulfhydryl CompoundsAntioxidantsAntitubercular AgentsArginineReactive Oxygen SpeciesSulfhydryl Compoundsbactericidal auxotrophyl-arginineMycobacterium tuberculosisoxidative damagereactive oxygen species

Identifiers

PMID30143580
PMCPMC6166831
OpenAlexW2888763868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.