Evidence map›Paper›PMID 30143531›Full record

ArticleThe Journal of biological chemistry2018

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation.

Rongde Qiu, Jun Zhang, Xin Xiang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cargo-Mediated Activation of Cytoplasmic DyneinFrontiers in cell and developmental biology · 2020
    Review
  15. Article
  16. Dynein activators and adaptors at a glance.Journal of cell science · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rongde QiuFrom the Department of Biochemistry and Molecular Biology, the Uniformed Services University-F. Edward Hébert School of Medicine, Bethesda, Maryland 20814.
Jun ZhangFrom the Department of Biochemistry and Molecular Biology, the Uniformed Services University-F. Edward Hébert School of Medicine, Bethesda, Maryland 20814.
Xin XiangFrom the Department of Biochemistry and Molecular Biology, the Uniformed Services University-F. Edward Hébert School of Medicine, Bethesda, Maryland 20814 xin.xiang@usuhs.edu.
Uniformed Services University of the Health Sciences · US

Funding

Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 2004 to 2013
$19.3M
Regulation of cytoplasmic dynein in vivoR01GM121850 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI XIANG, XIN · 2017 to 2020
$1.2M
Dissecting the interaction between dynein and early endosomesR01GM097580 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI XIANG, XIN · 2011 to 2014
$1.2M
NIGMS NIH HHS P01 GM068087NIGMS NIH HHS R01 GM097580NIGMS NIH HHS R01 GM121850
6 · The paper itself

Abstract

Cytoplasmic dynein binds its cargoes via the dynactin complex and cargo adapters, and the dynactin pointed-end protein p25 is required for dynein-dynactin binding to the early endosomal dynein adapter HookA (Hook in the fungus

Indexed as

Gene Expression Regulation, FungalActin CytoskeletonAmino Acid SequenceAnimalsAspergillus nidulansBinding SitesCloning, MolecularDynactin ComplexDyneinsEscherichia coliGene ExpressionGenetic VectorsHumansHydro-LyasesHyphaeKinesinsArp1 protein, Aspergillus fumagatusDynactin ComplexDyneinsHydro-LyasesKinesinsProtein SubunitsRecombinant ProteinsAspergilluscytoskeletondynactindyneinendosomeintracellular transportkinesinmicrotubulemolecular motorp25

Identifiers

PMID30143531
PMCPMC6177580
OpenAlexW2888093308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.