Evidence map›Paper›PMID 30143366›Full record

ArticleBioorganic & medicinal chemistry2018

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.

Christina Gates, Donald S Backos, Philip Reigan, Hye Jin Kang, Chris Koerner, Joseph Mirzaei, N R Natale

Open access · bronzeAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Lateral Metalation of Isoxazolo[3,4-Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christina GatesDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, United States.
Donald S BackosSkaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, United States.
Philip ReiganSkaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, United States.
Hye Jin KangPsychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Department of Pharmacology, School of Medicine, 2113 Genetics Medicine Building, 120 Mason Farm Road, Chapel Hill, NC 27599, United States.
Chris KoernerDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, United States.
Joseph MirzaeiDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, United States.
N R NataleDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, United States. Electronic address: nicholas.natale@umontana.edu.
University of Montana · USUniversity of North Carolina at Chapel Hill · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP20GM103546 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2012 to 2021
$19.2M
Understanding the molecular mechanism of pathogenesis of prion diseasesP20RR015583 · NCRR · UNIVERSITY OF MONTANA · PI KAVANAUGH, MICHAEL PATRICK · 2000 to 2009
$17.6M
NCATS NIH HHS UL1 TR001082NCRR NIH HHS P20 RR015583NIGMS NIH HHS P20 GM103546NIMH NIH HHS HHSN271201300017C
6 · The paper itself

Abstract

Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) are selective positive modulators of the metabotropic glutamate receptors (mGluRs) subtypes 2 and 4, with no functional cross reactivity at mGluR

Indexed as

Allosteric RegulationAnimalsIsoxazolesPyridazinesReceptors, Metabotropic GlutamateStructure-Activity RelationshipIsoxazolesmetabotropic glutamate receptor 2metabotropic glutamate receptor 4PyridazinesReceptors, Metabotropic Glutamate

Identifiers

PMID30143366
PMCPMC6675577
OpenAlexW2886365602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.