Evidence map›Paper›PMID 30143339›Full record

ArticleUltrasound in medicine & biology2018

Ultrasound Shear Wave Elastography: Variations of Liver Fibrosis Assessment as a Function of Depth, Force and Distance from Central Axis of the Transducer with a Comparison of Different Systems.

Manish Dhyani, Feixiang Xiang, Qian Li, Luzeng Chen, Changtian Li, Atul K Bhan, Brian Anthony, Joseph R Grajo, Anthony E Samir

Open access · greenAbstract readComparative Study
In one paragraph

Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Manish DhyaniDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Feixiang XiangDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China. Electronic address: xiangfx@hotmail.com.
Qian LiDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Luzeng ChenPeking University First Hospital Ultrasound Center, Beijing, China.
Changtian LiDepartment of Ultrasound, The Southern Building, Chinese PLA General Hospital, Beijing, China.
Atul K BhanDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Brian AnthonyDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Joseph R GrajoDepartment of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Anthony E SamirDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Massachusetts General Hospital · USChinese PLA General Hospital · CNHarvard University · USMassachusetts Institute of Technology · USPeking University · CNUnion Hospital · CNUniversity of Florida · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Reducing Variability in Hepatic Shear Wave ElastographyK23EB020710 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI SAMIR, ANTHONY EDWARD · 2016 to 2019
$781k
NIBIB NIH HHS HHSN268201300071CNIBIB NIH HHS K23 EB020710NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

We evaluated variation in fibrosis staging caused by depth, pre-load force and measurement off-axis distance on different ultrasound shear wave elastography (SWE) systems prospectively in 20 patients with diffuse liver disease. Shear wave speed (SWS) was measured with transient elastography, acoustic radiation force impulse (ARFI) and 2-D shear wave elastography (SWE). ARFI and 2-D-SWE measurements were obtained at different depths (3, 5 and 7 cm), with different pre-load forces (4, 7 and 10N and variable) and at 0, 2 and 4cm off the central axis of the transducer. A single, blinded pathologist staged fibrosis using the METAVIR system (F0-F4). Area under the receiver operating characteristic curve was charted to differentiate significant fibrosis (F ≥ 2). Depth was the only factor found to influence ARFI-derived values; no acquisition factors were found to affect 2-D-SWE SWS values. ARFI and 2-D-SWE for diagnosis of significant fibrosis at a depth of 7cm along the central axis had good diagnostic performance (areas under the receiver operating characteristic curve: 0.92 and 0.82, respectively), comparable to that of transient elastography. Further investigation of this finding will likely be of interest.

Indexed as

AdultAgedElasticity Imaging TechniquesFemaleHumansLiverLiver CirrhosisMaleMiddle AgedProspective StudiesTransducersYoung AdultDepthLiver fibrosisOff-axisPre-load forceShear waveUltrasound elastographyVariation

Identifiers

PMID30143339
PMCPMC6594152
OpenAlexW2888131918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.