Evidence map›Paper›PMID 30143148›Full record

ArticleCarbohydrate polymers2018

Chitosan microparticles based polyelectrolyte complex scaffolds for bone tissue engineering in vitro and effect of calcium phosphate.

Janitha M Unagolla, Turki E Alahmadi, Ambalangodage C Jayasuriya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Janitha M UnagollaBiomedical Engineering Program, Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43607, USA.
Turki E AlahmadiBiomedical Engineering Program, Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43607, USA.
Ambalangodage C JayasuriyaBiomedical Engineering Program, Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43607, USA; Department of Orthopedic Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Electronic address: a.jayasuriya@utoledo.edu.
University of Toledo · US

Funding

Multifunctional bone putty for craniomaxillofacial bone repairR01DE023356 · NIDCR · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JAYASURIYA, AMBALANGODAGE CHAMPA · 2013 to 2017
$2.0M
NIDCR NIH HHS R01 DE023356
6 · The paper itself

Abstract

Chitosan microparticles were mixed with chitosan and carboxymethyl cellulose solution to achieve a good binding between the microparticles. Three different compositions of scaffolds were made by varying the calcium phosphate (CaP) amount: 0%, 10%, and 20%. Potassium chloride was used as salt, to make pores inside the scaffolds after leaching out when immersed in phosphate buffer saline (PBS). Compressive strength and compressive modulus of both non-porous (before leaching out), and porous (after leaching out) scaffolds were measured according to the ASTM standards. The highest compressive strength of 27 MPa was reported on 10% CaP scaffolds while 20% CaP scaffolds showed the lowest. The increasing CaP content reduces the compressive strength of the scaffolds. The highest wet state compressive strength was reported on 0% CaP scaffolds with 0.36 MPs and 0.40 MPa at day 1 and day 3 respectively. In vitro cell culture studies showed good cell adhesion and cell proliferation on 10% CaP scaffolds.

Indexed as

Carboxymethyl celluloseCell proliferationChitosanCompressive strengthScaffold

Identifiers

PMID30143148
PMCPMC7433903
OpenAlexW2883527609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.