Evidence map›Paper›PMID 30143065›Full record

ArticleKidney international2018

Novel role for androgen signaling in pyelonephritis.

Christina B Ching, Brian Becknell

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Christina B ChingDivision of Pediatric Urology, Department of Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Brian BecknellCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Division of Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address: brian.becknell2@nationwidechildrens.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex differences in urinary tract infection (UTI) susceptibility and severity are known, but have historically focused on anatomic differences between males and females. Until recently, experimental UTI has been limited to female animals due to ease of transurethral bladder catheterization. Olson and colleagues have developed a model of experimental UTI independent of sex that relies on direct bladder inoculation and thus permits investigation of sex differences in UTI susceptibility. They now build upon their prior work in this model by implicating androgens as drivers of tubular invasion by uropathogenic Escherichia coli, which form luminal bacterial communities preceding renal abscess formation.

Indexed as

AbscessAndrogensAnimalsDisease Models, AnimalEscherichia coli InfectionsFemaleMalePyelonephritisUrinary Tract InfectionsUropathogenic Escherichia coliAndrogens

Identifiers

PMID30143065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.