Evidence map›Paper›PMID 30143058›Full record

ArticleBMC women's health2018

Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.

Frida Husseini-Akram, Sally Haroun, Signe Altmäe, Lottie Skjöldebrand-Sparre, Helena Åkerud, Inger Sundström Poromaa, Britt-Marie Landgren, Anneli Stavreus-Evers

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC women's health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Association Study of Hyaluronan-Binding Protein 2 (International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Frida Husseini-AkramDepartment of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden.
Sally HarounDepartment of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden.
Signe AltmäeCompetence Centre on Health Technologies, Tartu, Estonia.
Lottie Skjöldebrand-SparreDepartment of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden.
Helena ÅkerudDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Inger Sundström PoromaaDepartment of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden.
Britt-Marie LandgrenDepartment of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Anneli Stavreus-EversDepartment of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden. anneli.stavreus-evers@kbh.uu.se.ORCID 0000-0002-1092-0826
Uppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SEUniversidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women.

methodsThis study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied.

resultsPolymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001).

conclusionsVariations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate.

Indexed as

Polymorphism, GeneticAbortion, HabitualAdultCase-Control StudiesFemaleHumansHyaluronan ReceptorsLive BirthPregnancyPregnancy OutcomePregnant PeopleSerine EndopeptidasesHABP2 protein, humanHyaluronan ReceptorsSerine EndopeptidasesGenotypeHyaluronan–binding protein2 (HABP2)Recurrent miscarriage

Identifiers

PMID30143058
PMCPMC6108148
OpenAlexW2888082930

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.