ArticleBMC oral health2018
Odontogenic ameloblast-associated protein (ODAM) in gingival crevicular fluid for site-specific diagnostic value of periodontitis: a pilot study.
Article in BMC oral health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Reliability of partial-mouth periodontal examinations for diagnosing periodontal disease.Journal of periodontal & implant science · 2025Article
- Point-of-care diagnostic devices for periodontitis - current trends and urgent need.Sensors & diagnostics · 2024Review
- Alpha-Defensin 1: An Emerging Periodontitis Biomarker.Diagnostics (Basel, Switzerland) · 2023Article
- Influence of Random Plasmonic Metasurfaces on Fluorescence Enhancement.Materials (Basel, Switzerland) · 2022Article
- The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease.Frontiers in physiology · 2022Review
- A proline rich protein from the gingival seal around teeth exhibits antimicrobial properties against Porphyromonas gingivalis.Scientific reports · 2021Article
- Follicular dendritic cell-secreted protein gene expression is upregulated and spread in nifedipine-induced gingival overgrowth.Odontology · 2020Article
- Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval.Science advances · 2019Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOdontogenic Ameloblast-Associated Protein (ODAM) in gingival crevicular fluid (GCF) can provide evidence of the detachment of junctional epithelium from the tooth surface by periodontitis. This study sought to investigate the ability of ODAM to reflect the severity of periodontitis at a site-specific level; thus whether there was a relationship between clinical diagnostic parameters and the value of ODAM in GCF was analyzed.
methodsEight periodontitis patients with various severities were enrolled, and the clinical parameters and samples of GCF were obtained from 44 to 60 sites of each subject. The ODAM concentration was quantified by enzyme-linked immunosorbent assay. Correlation analyses between clinical parameters and ODAM values and unadjusted and adjusted (linear) mixed model analyses were performed. The accuracy of ODAM to reflect sites having a probing depth (PD) ≥ 5 mm and a positive bleeding on probing (BOP) was evaluated by receiver-operating characteristic analysis.
resultsA total of 424 GCF samples were collected. The mean ODAM concentration from each patient varied from 0.2 to 1.52 ng/ml. Correlations between PD or clinical attachment level (CAL) and ODAM values were found (p < 0.0001). An adjusted linear mixed model showed that PD or CAL were associated with ODAM values (p < 0.05). The area under the curve of ODAM, which reflected sites with PD ≥ 5 mm and positive BOP, was 0.661 (p < 0.0001).
conclusionThis result shows the possibility of GCF ODAM as a site-specific biomarker for periodontal tissue destruction.
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