Evidence map›Paper›PMID 30142886›Full record

Trial reportNutrients2018

Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes.

Jane Bowen, Emily Brindal, Genevieve James-Martin, Manny Noakes

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04953650 (The Effectiveness of Intermittent Fasting Towards Elevated Blood Pressure Among Civil Servants in Aceh), which is not on this map. Cited by 41 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04953650 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effectiveness of Intermittent Fasting Towards Elevated Blood Pressure Among Civil Servants in Aceh

TypeinterventionalSponsorUniversity of MalayaRan2021 to 2022Enrolled140ConditionsIntermittent Fasting, Elevated Blood PressureArmsIntermittent fasting, No intervention
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
    Pooled it
  8. Pooled it
  9. The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
    Pooled it
  10. Intermittent fasting and weight loss: Systematic review.Canadian family physician Medecin de famille canadien · 2020
    Pooled it
  11. Trial
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  15. Trial
  16. The impact of intermittent energy restriction on women's health.The Proceedings of the Nutrition Society · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jane BowenCSIRO Health and Biosecurity, Adelaide, SA 5000, Australia. Jane.Bowen@csiro.au.
Emily BrindalCSIRO Health and Biosecurity, Adelaide, SA 5000, Australia. emily.brindal@csiro.au.
Genevieve James-MartinCSIRO Health and Biosecurity, Adelaide, SA 5000, Australia. Genevieve.James-Martin@csiro.au.
Manny NoakesCSIRO Health and Biosecurity, Adelaide, SA 5000, Australia. manny.noakes@csiro.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Higher-protein diets, meal replacements, and greater early weight loss have separately been associated with greater weight loss. We compared a high-protein, meal replacement program with daily energy restriction (DER) to one which provided greater energy restriction adding alternate day fasting (ADF + DER; alternating days of modified-fasting and DER plus 1

Indexed as

Caloric RestrictionDiet, High-ProteinFastingMealsAdultBiomarkersBlood GlucoseBlood PressureBody Mass IndexCholesterol, LDLC-Reactive ProteinDietary ProteinsFemaleFerritinsFolic AcidHumansBiomarkersBlood GlucoseCholesterol, LDLC-Reactive ProteinDietary ProteinsFerritinsFolic AcidInsulinThiamineTransferrinTriglyceridesVitamin B 12Vitamin DZincfastingmeal replacementweight loss

Identifiers

PMID30142886
PMCPMC6165084

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.