Evidence map›Paper›PMID 30142581›Full record

ArticleBiosensors & bioelectronics2018

In situ, amplification-free double-stranded mutation detection at 60 copies/ml with thousand-fold wild type in urine.

Ceyhun Kirimli, Selena Lin, Ying-Hsiu Su, Wei-Heng Shih, Wan Y Shih

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ceyhun KirimliSchool of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, United States.
Selena LinDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19104, United States.
Ying-Hsiu SuDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19104, United States; The Baruch S. Blumberg Institute, Doylestown, PA 18901, United States.
Wei-Heng ShihDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, United States.
Wan Y ShihSchool of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, United States. Electronic address: shihwy@drexel.edu.
Drexel University · USBaruch S. Blumberg Institute · US

Funding

Development of cell-free DNA assays for HCC screening and liquid biopsyR01CA202769 · NCI · BARUCH S. BLUMBERG INSTITUTE · PI SU, YING-HSIU · 2016 to 2020
$2.1M
Rapid, Accurate, and Low-Cost Stool Clostridium difficile Genetic TestR41AI112224 · NIAID · LENIMA FIELD DIAGNOSTICS, LLC · PI SHIH, WAN Y. · 2014 to 2014
$300k
A Low-Cost Portable Multiplex Serum Molecular Test for HBV and HCV DetectionR41AI120445 · NIAID · LENIMA FIELD DIAGNOSTICS, LLC · PI SHIH, WAN Y. · 2015 to 2015
$300k
NCI NIH HHS R01 CA202769NIAID NIH HHS R41 AI112224NIAID NIH HHS R41 AI120445
6 · The paper itself

Abstract

We have investigated amplification-free in situ double-stranded mutation detection in urine in the concentration range 10

Indexed as

Biosensing TechniquesDNA, ViralHepatitis BHepatitis B virusHumansLimit of DetectionMutationPoint MutationUrinalysisDNA, ViralAmplification-free mutation detectionHigh-specificity mutation detectionIsolation-free mutation detectionLabel-free double-stranded DNA detectionLabel-free mutation detection

Identifiers

PMID30142581
PMCPMC6524543
OpenAlexW2887118160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.