ArticlePloS one2018
Trichoderma asperelloides ethanolic extracts efficiently inhibit Staphylococcus growth and biofilm formation.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Combined biocontrol to tomato gray mold and inhibition via multi-mechanistic antifungal activity to Botrytis cinerea by Trichoderma harzianum T4.Archives of microbiology · 2026Article
- Functional Peptides: Comparing Synthetic and Sequence-Engineered Antibiofilm Pharmaceutics.Pharmaceutics · 2026Review
- Inhibitory effects ofPeerJ · 2025Article
- Unveiling the anticancer potential of the ethanolic extract fromFrontiers in pharmacology · 2024Article
- Ethanolic Extract of the FungusFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Fungi from the widely distributed genus Trichoderma are of great biotechnological interest, being currently used in a vast range of applications. Here, we report that high-molecular weight fraction (HWF) derived from Trichoderma asperelloides ethanolic extract exhibits antibiotic activity against staphylococcal biofilms. The antibacterial and anti-biofilm properties of T. asperelloides extracts were evaluated by well-established assays in Staphylococcus aureus ATCC strains (29213 and 6538) and in one clinical isolate from bovine mastitis. The HWF from T. asperelloides eradicated S. aureus by causing substantial matrix de-structuring and biomass reduction (p < 10-5) at concentrations as low as 2.3 μg mL-1. Additionally, we present ultra-structure analysis by the use of scanning electron microscopy as well as transmission microscopy, which showed that T. asperelloides killed cells through cell wall and membrane disturbance. Remarkably, the HWF from T. asperelloides killed S. aureus and eradicated its biofilms in a greater performance than gentamicin (p < 10-5), a known potent antibiotic against S. aureus. Our results indicate that extract from T. asperelloides may represent a promising candidate for the development of new antibiotics against gram-positive bacteria.
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Registered trials
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