ArticleJournal of acquired immune deficiency syndromes (1999)2018
Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals.
Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Human Immunodeficiency Virus on Lung Function and Structure: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society · 2025Pooled it
- Pooled it
- Sequelae of Immunocompromised Host Pneumonia.Clinics in chest medicine · 2025Review
- Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review.HIV/AIDS (Auckland, N.Z.) · 2025Review
- Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.AIDS research and human retroviruses · 2023Article
- Article
- Pulmonary function tests and their associated factors in people living with HIV at Jimma medical center; Ethiopia: a comparative cross-sectional study.Frontiers in reproductive health · 2023Article
- COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS).Annals of epidemiology · 2022Article
- Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.Annals of the American Thoracic Society · 2022Article
- Chronic Human Immunodeficiency Virus Infection Is Associated with Accelerated Decline of Forced Expiratory Volume in 1 Second among Women but Not among Men: A Longitudinal Cohort Study in Uganda.Annals of the American Thoracic Society · 2022Article
- Dyspnea and Pulmonary Function Among Participants in the Multicenter AIDS Cohort Study Using Protease Inhibitors: A Cross-Sectional Study.AIDS research and human retroviruses · 2022Article
- Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021Review
- Predictors of impaired pulmonary function in people living with HIV in an urban African setting.Southern African journal of HIV medicine · 2021Article
- Lung function in men with and without HIV.AIDS (London, England) · 2020Observational
- Obstructive Lung Disease in HIV-Phenotypes and Pathogenesis.Current HIV/AIDS reports · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundHIV is an independent risk factor for chronic obstructive pulmonary disease; however, baseline risk factors for lung function decline remain largely unknown in this population.
methodsHIV-infected participants in the Pittsburgh Lung HIV Cohort with at least 3 pulmonary function measurements between 2007 and 2016 were included. Pulmonary function testing including postbronchodilator (BD) spirometry and diffusion capacity for carbon monoxide (DLco) was performed every 18 months. We used a mixed-effect linear model to evaluate factors associated with pulmonary function testing and DLco decline and logistic regression models to evaluate factors associated with rapid FEV1 decline (defined as >80 mL per year) and any DLco decline.
resultsTwo hundred eighty-five HIV-infected participants were included. Median baseline CD4 cell count was 521 cells per micro liter, 61.9% had an undetectable HIV viral load at baseline, and 78.5% were receiving ART. Approximately 20% of participants met Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for a diagnosis of chronic obstructive pulmonary disease at baseline. Older age and baseline GOLD stage 1 compared with stage 0 were associated with faster decline in post-BD FEV1%, whereas female sex was associated with slower decline. Similarly, female sex was associated with slower decline in DLco%. HIV-related factors including CD4 cell count, viral load, and ART use were not significantly associated with pulmonary function decline.
conclusionsOlder age, male sex, and higher baseline GOLD stage were associated with more rapid post-BD FEV1% decline in HIV-infected individuals.
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