ArticleAnalytical chemistry2018
Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk.
Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- On the Design, Fabrication, and Operation of Electrochemical Aptamer-Based Sensors.ACS sensors · 2025Review
- Current State of the Art and Potential for Construction and Demolition Waste Processing: A Scoping Review of Sensor-Based Quality Monitoring and Control for In- and Online Implementation in Production Processes.Sensors (Basel, Switzerland) · 2025Review
- Carboxylate-Terminated Electrode Surfaces Improve the Performance of Electrochemical Aptamer-Based Sensors.ACS applied materials & interfaces · 2025Article
- MercuryMikrochimica acta · 2024Article
- Codeposition Enhances the Performance of Electrochemical Aptamer-Based Sensors.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- On the Rational Design of Cooperative Receptors.Annual review of biophysics · 2023Review
- Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices.Lab on a chip · 2023Review
- Real-Time,ACS sensors · 2022Review
- Single-Molecule Mechanochemical Sensing.Accounts of chemical research · 2022Article
- Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Advances and Challenges in Small-Molecule DNA Aptamer Isolation, Characterization, and Sensor Development.Angewandte Chemie (International ed. in English) · 2021Review
- Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk.Micromachines · 2021Review
- Silver Nanocubes as Electrochemical Labels for Bioassays.ACS sensors · 2021Article
- Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors.ACS applied materials & interfaces · 2021Article
- Fabrication of Aptamer-Modified Paper Electrochemical Devices for On-Site Biosensing.Angewandte Chemie (International ed. in English) · 2021Article
- A wrinkled structure of gold film greatly improves the signaling of electrochemical aptamer-based biosensors.RSC advances · 2020Article
- Detection of melamine based on the suppressed anodic response of uric acid by a Au-Ag nanoparticles modified glassy carbon electrode.Journal of food and drug analysis · 2020Article
- A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials.Nature materials · 2020Article
- Real-Time Monitoring of a Protein Biomarker.ACS sensors · 2020Article
- Beyond Sensitive and Selective Electrochemical Biosensors: Towards Continuous, Real-Time, Antibiofouling and Calibration-Free Devices.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The ability to monitor specific molecules in real-time directly in a flowing sample stream and in a manner that does not adulterate that stream could greatly augment quality control in, for example, food processing and pharmaceutical manufacturing. Because they are continuous, reagentless, and able to work directly in complex samples, electrochemical DNA-based (E-DNA) sensors, a modular and, thus, general sensing platform, are promising candidates to fill this role. In support, we describe here an E-DNA sensor supporting the continuous, real-time measurement of melamine in flowing milk. Using target-driven DNA triplex formation to generate an electrochemical output, the sensor responds to rising and falling melamine concentration in seconds without contaminating the product stream. The continuous, autonomous, real-time operation of sensors such as this could provide unprecedented safety, convenience, and cost-effectiveness relative to the batch processes historically employed in molecular quality control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.