ArticleHepatology (Baltimore, Md.)2019
mTOR Signaling in X/A-Like Cells Contributes to Lipid Homeostasis in Mice.
Article in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Intact mTOR signaling in gastric X/A-like cells is required for bone homeostasis.Frontiers in endocrinology · 2026Article
- Enteroendocrine cell differentiation: Implications for human disease.Molecular and cellular endocrinology · 2025Review
- Article
- Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.Nature metabolism · 2024Article
- Signaling pathways in obesity: mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2022Review
- Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.Frontiers in endocrinology · 2022Article
- Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization.Journal of cellular physiology · 2021Article
- Ghrelin signalling is dysregulated in male but not female offspring in a rat model of maternal vertical sleeve gastrectomy.Journal of neuroendocrinology · 2021Article
- Ghrelin Based Therapy of Metabolic Diseases.Current medicinal chemistry · 2021Review
- mTOR Pathway is Involved in Energy Homeostasis Regulation as a Part of the Gut-Brain Axis.International journal of molecular sciences · 2020Review
- DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling.EMBO reports · 2020Article
- Physiological Effect of Ghrelin on Body Systems.International journal of endocrinology · 2020Review
- Mechanisms controlling hormone secretion in human gut and its relevance to metabolism.The Journal of endocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28-aa peptide hormone produced by gastric X/A-like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought to control global lipid metabolism via the manipulation of gastric mTOR signaling in X/A-like cells. We established a ghrl-cre transgene in which the Cre enzyme is expressed in X/A-like cells under the control of the ghrelin-promoter. mTOR
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.