Evidence map›Paper›PMID 30141248›Full record

ArticleBrain and behavior2018

Circulating endothelial progenitor cells and endothelial cells in moyamoya disease.

Xiang-Yang Bao, Yan-Na Fan, Yi Liu, Qian-Nan Wang, Yong Zhang, Bing Zhu, Bing Liu, Lian Duan

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Endothelial progenitor cells and cerebral small vessel disease inCerebral circulation - cognition and behavior · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiang-Yang BaoDepartment of Neurosurgery, The Center for Cerebral Vascular Disease, PLA, 307th Hospital, PLA, Beijing, China.
Yan-Na FanCenter of Interventional Radiology for Oncology, 307th Hospital, PLA, Beijing, China.
Yi LiuLab of Tumor Molecular, 307th Hospital, PLA, Beijing, China.
Qian-Nan WangDepartment of Neurosurgery, The Center for Cerebral Vascular Disease, PLA, 307th Hospital, PLA, Beijing, China.
Yong ZhangDepartment of Neurosurgery, The Center for Cerebral Vascular Disease, PLA, 307th Hospital, PLA, Beijing, China.
Bing ZhuDepartment of Neurosurgery, The Center for Cerebral Vascular Disease, PLA, 307th Hospital, PLA, Beijing, China.
Bing LiuLab of Tumor Molecular, 307th Hospital, PLA, Beijing, China.
Lian DuanDepartment of Neurosurgery, The Center for Cerebral Vascular Disease, PLA, 307th Hospital, PLA, Beijing, China.ORCID 0000-0003-3586-4653
307th Hospital of Chinese People’s Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is no well-recognized biomarker for accurately predicting outcome in the presence of moyamoya disease (MMD), a progressive occlusive cerebrovascular disease of the internal carotid arteries or their branches. The aim of this study was to investigate the presence of endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in MMD and correlate the findings with clinical features.

methodsPatients with MMD (n = 66) were compared with healthy controls (n = 81). Blood samples were obtained from an antecubital vein and analyzed using flow cytometry. EPCs were defined as CD31

resultsThe CEC counts were significantly higher in the patients than in the controls (p = 0.008). In multivariate analysis, EPC counts were independently associated with age of patients with MMD (p = 0.049) and CEC counts were independently negatively associated with concomitant disease such as hypertension, diabetes mellitus, and coronary heart disease (p = 0.034).

conclusionsThis is the first study to investigate the presence of CECs in the plasma of patients with MMD, and the amount of CECs was negatively correlated with concomitant disease in these patients.

Indexed as

Endothelial CellsEndothelial Progenitor CellsAdultAgedBiomarkersCell CountFemaleFlow CytometryHumansMaleMiddle AgedMoyamoya DiseaseYoung AdultBiomarkerscirculating endothelial cellsendothelial progenitor cellsflow cytometrymoyamoya disease

Identifiers

PMID30141248
PMCPMC6160662
OpenAlexW2888080261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.