ArticleJournal of microbiology (Seoul, Korea)2018
Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.
Article in Journal of microbiology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Genetic, virulence, and antimicrobial resistance characteristics associated with distinct morphotypes in ST11 carbapenem-resistantVirulence · 2024Article
- Development and validation of a quick, automated, and reproducible ATR FT-IR spectroscopy machine-learning model forJournal of clinical microbiology · 2024Article
- Animal models ofFrontiers in microbiology · 2024Review
- Clinical and Genomic Characterization of Carbapenem-ResistantMicroorganisms · 2023Article
- Species identification, antibiotic resistance, and virulence inFrontiers in microbiology · 2023Article
- Comparison of Virulence between Two Main Clones (ST11 and ST307) ofMicroorganisms · 2022Article
- Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.Microbiology spectrum · 2022Article
- Increased Capsule Thickness and Hypermotility Are Traits of Carbapenem-ResistantOpen forum infectious diseases · 2021Article
- Two Distinct Genotypes of KPC-2-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Change of Hypermucoviscosity in the Development of Tigecycline Resistance in HypervirulentMicroorganisms · 2020Article
- Animal infection models using non-mammals.Microbiology and immunology · 2020Review
- Epidemiology of β-Lactamase-Producing Pathogens.Clinical microbiology reviews · 2020Review
- Co-introduction of plasmids harbouring the carbapenemase genes, blaJournal of biomedical science · 2020Article
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Authors and funding
11 authors.
Funding
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Abstract
Nine Klebsiella pneumoniae isolates coproducing NDM-1 and OXA-232 carbapenemases were successively isolated from a single patient. Although they were isolated simultaneously and were isogenic, they presented different colony phenotypes (matt and mucoid). All nine isolates were resistant to most antibiotics except colistin and fosfomycin. In addition, matt-type isolates were resistant to tigecycline. No differences were detected in the cps cluster sequences, except for the insertion of IS5 in the wzb gene of two matt-type isolates. In vitro virulence assays based on production of capsular polysaccharide, biofilm formation, and resistance to human serum indicated that the mucoid-type isolates were significantly more virulent than the matt-type. In addition, mucoid-type isolates showed higher survival rates than the matt-type ones in infection experiments in the fruit fly, suggesting a higher virulence of K. pneumoniae isolates with a mucoid phenotype. To our knowledge, this is the first report of K. pneumoniae colonies with different phenotypes being isolated from the same sample. In addition, we show that virulence varies with colony phenotype. Dissemination of K. pneumoniae isolates expressing both antibiotic resistance and high virulence would constitute a great threat.
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