ArticleMethods in molecular biology (Clifton, N.J.)2018
Using Nesprin Tension Sensors to Measure Force on the LINC Complex.
Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Extremely Low Mechanical Force Generated by Nano-Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- miR-548t-3p impairs nuclear mechanosensitivity and focal adhesion via lamin A/C downregulation.Biophysical journal · 2025Article
- Myosin II tension sensors visualize force generation within the actin cytoskeleton in living cells.Journal of cell science · 2024Article
- Nuclear curvature determines Yes-associated protein localization and differentiation of mesenchymal stem cells.Biophysical journal · 2024Article
- Pathogenic tau decreases nuclear tension in cultured neurons.Frontiers in aging · 2023Article
- The yellow brick road to nuclear membrane mechanotransduction.APL bioengineering · 2022Review
- Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.Nature communications · 2022Article
- Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts.Nature biomedical engineering · 2021Article
- Image-Based Elastography of Heterochromatin and Euchromatin Domains in the Deforming Cell Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- Fluids and their mechanics in tumour transit: shaping metastasis.Nature reviews. Cancer · 2020Review
- Characterization of 3D Printed Stretching Devices for Imaging Force Transmission in Live-Cells.Cellular and molecular bioengineering · 2019Article
- Role of KASH domain lengths in the regulation of LINC complexes.Molecular biology of the cell · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Mechanotransduction, or the process by which mechanical forces regulate cellular functions, is increasingly studied in a variety of different physiological and pathological contexts. Although these forces are most often studied at cell-matrix and cell-cell adhesions, recent work has shown that the nuclear LINC complex is also subject to mechanical forces. Here we describe how to use a FRET-based biosensor, known as TSmod, in the LINC complex protein nesprin-2G. This approach allows for measurement of LINC complex forces in living cells with spatial-temporal resolution.
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