ArticleVirchows Archiv : an international journal of pathology2018
Immunohistochemical classification of gastric cancer based on new molecular biomarkers: a potential predictor of survival.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.Molecular oncology · 2021Pooled it
- CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2.Discover oncology · 2025Article
- Mixed adenoma-neuroendocrine tumor of the stomach: analysis of nine cases with literature review.Virchows Archiv : an international journal of pathology · 2025Review
- Liquid biopsy for gastric cancer: Techniques, applications, and future directions.World journal of gastroenterology · 2024Review
- Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration.International journal of molecular sciences · 2024Review
- Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy.International journal of molecular sciences · 2023Review
- Article
- Accuracy evaluation of combining gastroscopy, multi-slice spiral CT, Her-2, and tumor markers in gastric cancer staging diagnosis.World journal of surgical oncology · 2022Article
- Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.The British journal of surgery · 2022Article
- The seen and the unseen: Molecular classification and image based-analysis of gastrointestinal cancers.Computational and structural biotechnology journal · 2022Review
- Microsatellite instability in Chinese gastric cancer and its correlation with clinical characteristics.Journal of gastrointestinal oncology · 2021Article
- Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer.Bioengineered · 2021Article
- Are Borrmann's Types of Advanced Gastric Cancer Distinct Clinicopathological and Molecular Entities? A Western Study.Cancers · 2021Article
- Her2-Positive and Microsatellite Instability Status in Gastric Cancer-Clinicopathological Implications.Diagnostics (Basel, Switzerland) · 2021Article
- Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy.BMC gastroenterology · 2019Article
- Clinical Implementation of Precision Medicine in Gastric Cancer.Journal of gastric cancer · 2019Review
- Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers.Journal of clinical medicine · 2019Article
- [Bioinformatics analysis of expression and function of EXD3 gene in gastric cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
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Authors and funding
7 authors.
Funding
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Abstract
Several classification systems have been described for stratifying patients with gastric carcinoma (GC). However, their prognostic value is low, and there is an urgent need for identification of molecular markers and development of new classifications. Retrospective study of 206 cases of GC diagnosed and surgically resected in our hospital between 2000 and 2017. Clinicopathological features of all cases were assessed and tissue microarrays were constructed for immunohistochemical (IHC) study. Patients were stratified based on IHC results. Mean patient age was 71 years and most patients were male (54.6%). Most tumors were located in the gastric antrum and body, and they were mostly fungoid or ulcerative lesions. GC were mainly intestinal-type tumors and 60.3% were diagnosed at pT3. 56.2% of patients showed recurrences and 29.4% died due to GC. According to our IHC classification, 23.5% of tumors showed microsatellite instability, 6% were E-cadherin negative, 53.5% were stable-p53 not overexpressed, and 17% were stable with p53 overexpression. IHC classification was significantly correlated with patient gender, gross morphology, Laurén classification, tumor necrosis, perineural infiltration, type of leading edge, and patient outcome. Multivariate analysis showed that IHC subtype was significantly and independently associated with overall survival, together with clinical symptoms, signet cell phenotype, tumor grade and vessel invasion. The application of IHC classifications based on molecular biomarkers in clinical practice can aid in the stratification of GC patients. More studies are needed to evaluate the reproducibility and clinical significance of these classifications.
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