ArticleEye and vision (London, England)2018
Retinal tissue hypoperfusion in patients with clinical Alzheimer's disease.
Article in Eye and vision (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.Translational vision science & technology · 2026Article
- Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.PloS one · 2026Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Relationship of retinal capillary plexus and ganglion cell complex with mild cognitive impairment and dementia.Eye (London, England) · 2023Article
- Article
- Implications of fibrotic extracellular matrix in diabetic retinopathy.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.International journal of molecular sciences · 2022Review
- Age dependence of retinal vascular plexus attenuation in the triple transgenic mouse model of Alzheimer's disease.Experimental eye research · 2022Article
- Assessing the validity of a cross-platform retinal image segmentation tool in normal and diseased retina.Scientific reports · 2021Article
- Exploratory study of non-invasive, high-resolution functional macular imaging in subjects with diabetic retinopathy.International journal of ophthalmology · 2021Article
- Visual Function and Disability Are Associated with Increased Retinal Volumetric Vessel Density in Patients with Multiple Sclerosis.American journal of ophthalmology · 2020Article
- Measurement of Retinal Microvascular Blood Velocity Using Erythrocyte Mediated Velocimetry.Scientific reports · 2019Article
- Retinal Tissue Perfusion in Patients with Multiple Sclerosis.Current eye research · 2019Article
- Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.Investigative ophthalmology & visual science · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundIt remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer's disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer's disease (CAD).
methodsTwenty-four CAD patients and 19 cognitively normal (CN) age-matched controls were recruited. A retinal function imager (RFI, Optical Imaging Ltd., Rehovot, Israel) was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the fovea. Blood flow volumes of arterioles (entering the macular region) and venules (exiting the macular region) of the supplied area were calculated. Macular blood flow was calculated as the average of arteriolar and venular flow volumes. Custom ultra-high-resolution optical coherence tomography (UHR-OCT) was used to calculate macular tissue volume. Automated segmentation software (Orion, Voxeleron LLC, Pleasanton, CA) was used to segment six intra-retinal layers in the 2.5 mm (diameter) area centered on the fovea. The inner retina (containing vessel network), including retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), inner nuclear layer (INL) and outer plexiform layer (OPL), was segmented and tissue volume was calculated. Perfusion was calculated as the flow divided by the tissue volume.
resultsThe tissue perfusion in CAD patients was 2.58 ± 0.79 nl/s/mm
conclusionsThis study is the first to show decreased retinal tissue perfusion that may be indicative of diminished tissue metabolic activity in patients with clinical Alzheimer's disease.
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