ArticleBioMed research international2018
Autophagy Is Independent of the Chondroprotection Induced by Platelet-Rich Plasma Releasate.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: anFrontiers in bioengineering and biotechnology · 2026Article
- Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy.Nature reviews. Rheumatology · 2024Review
- The Effects of the Combination of Rhein and Platelet-Rich Plasma on Human Articular Chondrocytes.Life (Basel, Switzerland) · 2023Article
- Regenerative Medicine: Pharmacological Considerations and Clinical Role in Pain Management.Current pain and headache reports · 2022Review
- Unbiased transcriptome mapping and modeling identify candidate genes and compounds of osteoarthritis.Frontiers in pharmacology · 2022Article
- Platelet-Rich Plasma in the Treatment of Facet Mediated Low Back Pain: A Comprehensive Review.Orthopedic reviews · 2022Review
- Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy.European journal of medical research · 2021Article
- Platelet-Rich Plasma for the Treatment of Low Back Pain: a Comprehensive Review.Current pain and headache reports · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet-rich plasma (PRP) has been shown to be a promising therapeutic agent against osteoarthritis (OA), whereas its chondroprotection mechanism is not fully elucidated. Autophagy is considered an important biological process throughout the development of OA. Therefore, the objective of the present study is to investigate the role of autophagy in the chondroprotection and compare the effects of releasate between L-PRP and P-PRP.
methodsPRP were prepared from rat blood. Rat chondrocytes pretreated in the presence or absence of interleukin-1 beta (IL-1
results
conclusionsPRP releasate promoted the anabolic gene expression, relieved inflammatory stress in chondrocytes, and ameliorated cartilage degeneration, but autophagy was independent of these processes.
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Registered trials
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