Evidence map›Paper›PMID 30140701›Full record

ArticleBioMed research international2018

Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way.

Zhijie Han, Jiaojiao Qu, Jiehong Zhao, Xiao Zou

Abstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. MIF Tautomerase Inhibition Protects Neurons From Immune-Mediated Cell Death.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  3. MIF contribution to progressive brain diseases.Journal of neuroinflammation · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Genetic Variants of thePharmacogenomics and personalized medicine · 2021
    Article
  8. A Polymorphism Within theFrontiers in immunology · 2020
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhijie HanInnovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China.
Jiaojiao QuInstitute of Fungus Resources, College of Life Sciences, Guizhou University, Guiyang, 550025, China.
Jiehong ZhaoCollege of Pharmacy, Guiyang University of Chinese Medicine, Guian New Area, 550025, China.
Xiao ZouInstitute of Fungus Resources, College of Life Sciences, Guizhou University, Guiyang, 550025, China.ORCID 0000-0002-3666-5536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a sex-specific autoimmune disease involving central nervous system. Previous studies determined that macrophage migration inhibitory factor (MIF) and its homologue D-dopachrome tautomerase (DDT) sex-specifically affect MS progression. Moreover, other studies reported that rs755622 polymorphism in promoter region of

Indexed as

Polymorphism, GeneticDisease ProgressionFemaleGene FrequencyHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMultiple SclerosisPromoter Regions, GeneticRNASex Factorsdopachrome isomeraseIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsRNA

Identifiers

PMID30140701
PMCPMC6081589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.