ArticleFrontiers in public health2018
Live Poultry Trading Drives China's H7N9 Viral Evolution and Geographical Network Propagation.
Article in Frontiers in public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings.Viruses · 2025Pooled it
- Environmental circulation of multiple avian influenza subtypes and potential association with human infections in central China.Frontiers in cellular and infection microbiology · 2026Article
- Investigation of human infection with H5N6 avian influenza cases in Sichuan Province from 2014 to 2024: a retrospective study.Frontiers in public health · 2025Article
- Conflicting Evidence between Clinical Perception and Molecular Epidemiology: The Case of Fowl Adenovirus D.Animals : an open access journal from MDPI · 2023Article
- Bayesian phylodynamics reveals the transmission dynamics of avian influenza A(H7N9) virus at the human-live bird market interface in China.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Risk Factors Contributing to Highly Pathogenic Avian Influenza H5N6 in China, 2014-2021: Based on a MaxEnt Model.Transboundary and emerging diseases · 2023Article
- A dataset of a proxy variable for the poultry trade flows in China.Scientific data · 2022Article
- The Emergence, Diversification, and Transmission of Subgroup J Avian Leukosis Virus Reveals that the Live Chicken Trade Plays a Critical Role in the Adaption and Endemicity of Viruses to the Yellow-Chickens.Journal of virology · 2022Article
- Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021.Frontiers in microbiology · 2022Article
- Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID-19 pandemic.Journal of medical virology · 2021Article
- Phylogeography of Highly Pathogenic H5 Avian Influenza Viruses in China.Virologica Sinica · 2020Article
- Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong.Virus evolution · 2020Article
- Genetic diversity, phylogeography, and evolutionary dynamics of highly pathogenic avian influenza A (H5N6) viruses.Virus evolution · 2020Article
- Global patterns of avian influenza A (H7): virus evolution and zoonotic threats.FEMS microbiology reviews · 2019Review
- One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The on-going reassortment, human-adapted mutations, and spillover events of novel A(H7N9) avian influenza viruses pose a significant challenge to public health in China and globally. However, our understanding of the factors that disseminate the viruses and drive their geographic distributions is limited. We applied phylogenic analysis to examine the inter-subtype interactions between H7N9 viruses and the closest H9N2 lineages in China during 2010-2014. We reconstructed and compared the inter-provincial live poultry trading and viral propagation network via phylogeographic approach and network similarity technique. The substitution rates of the isolated viruses in live poultry markets and the characteristics of localized viral evolution were also evaluated. We discovered that viral propagation was geographically-structured and followed the live poultry trading network in China, with distinct north-to-east paths of spread and circular transmission between eastern and southern regions. The epicenter of H7N9 has moved from the Shanghai-Zhejiang region to Guangdong Province was also identified. Besides, higher substitution rate was observed among isolates sampled from live poultry markets, especially for those H7N9 viruses. Live poultry trading in China may have driven the network-structured expansion of the novel H7N9 viruses. From this perspective, long-distance geographic expansion of H7N9 were dominated by live poultry movements, while at local scales, diffusion was facilitated by live poultry markets with highly-evolved viruses.
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