Evidence map›Paper›PMID 30140628›Full record

ArticleInternational journal of ophthalmology2018

Inhibition of retinal angiogenesis by gold nanoparticles

Ni Shen, Rui Zhang, Hao-Rui Zhang, Hao-Yang Luo, Wei Shen, Xin Gao, Da-Zhi Guo, Jie Shen

Abstract read
In one paragraph

Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  12. TRPC6-Mediated CaNeurochemical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ni ShenDepartment of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Rui ZhangDepartment of Ophthalmology, Changhai Hospital, the Second Military Medical Univerisity, Shanghai 200433, China.
Hao-Rui ZhangDepartment of Ophthalmology, Changhai Hospital, the Second Military Medical Univerisity, Shanghai 200433, China.
Hao-Yang LuoSchool of Life Science, Fudan University, Shanghai 200082, China.
Wei ShenDepartment of Ophthalmology, Changhai Hospital, the Second Military Medical Univerisity, Shanghai 200433, China.
Xin GaoDepartment of Ophthalmology, Changhai Hospital, the Second Military Medical Univerisity, Shanghai 200433, China.
Da-Zhi GuoDepartment of Hyperbaric Oxygen, Navy General Hospital, Beijing 100037, China.
Jie ShenDepartment of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effect of gold nanoparticles on retinal angiogenesis

methodsSeed growth method was used to synthesize gold nanoparticles (GNPs). The size, zeta potential, absorption spectrum and morphology of GNPs were identified using Malvern Nano-ZS, multimode reader (BioTek synergy2) and transmission electron microscope. Cell viability was analyzed using cell counting kit-8 method and cell growth was assessed with EdU kit. Transwell chamber was used to investigate cell migration. Tube formation method was used to assess the angiogenic property

resultsThe GNPs synthesized were uniform and well dispersed. GNPs of 10 µg/mL and 20 µg/mL were able to inhibit human umbilical vein endothelial cells proliferation (50% and 72% separately,

conclusionThe present study suggests that GNPs are able to inhibit retinal neovascularization

Indexed as

autophagygold nanoparticlesnanomedicineoxygen induced retinopathyretinal angiogenesis

Identifiers

PMID30140628
PMCPMC6090107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.