Evidence map›Paper›PMID 30140607›Full record

ArticleNeuroImage. Clinical2017

Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder.

Janna Marie Bas-Hoogendam, Henk van Steenbergen, J Nienke Pannekoek, Jean-Paul Fouche, Christine Lochner, Coenraad J Hattingh, Henk R Cremers, Tomas Furmark, Kristoffer N T Månsson, Andreas Frick and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Article
  9. A Proton Magnetic Resonance Spectroscopy (International journal of molecular sciences · 2025
    Article
  10. Autonomic Readiness for Social Threats in Patients with Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
  11. Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025
    Review
  12. Article
  13. Review
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  15. Hemispheric asymmetries in mental disorders: evidence from rodent studies.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Janna Marie Bas-HoogendamInstitute of Psychology, Leiden University, Leiden, The Netherlands.
Henk van SteenbergenInstitute of Psychology, Leiden University, Leiden, The Netherlands.
J Nienke PannekoekNeuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Imperial College London, United Kingdom.
Jean-Paul FoucheDepartment of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
Christine LochnerSU/UCT MRC Unit on Anxiety & Stress Disorders, South Africa.
Coenraad J HattinghDepartment of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
Henk R CremersDepartment of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Tomas FurmarkDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Kristoffer N T MånssonDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Andreas FrickDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Jonas EngmanDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Carl-Johan BoraxbekkUmeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Per CarlbringDepartment of Psychology, Stockholm University, Stockholm, Sweden.
Gerhard AnderssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mats FredriksonDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Jutta PeterbursInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Heide KlumppDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
K Luan PhanDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Karin RoelofsBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Dick J VeltmanDepartment of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Marie-José van TolDepartment of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (

Indexed as

Magnetic Resonance ImagingAdolescentAdultBrainFemaleHumansImage Processing, Computer-AssistedInternational CooperationMalePhobia, SocialPsychiatric Status Rating ScalesYoung AdultGray matterMega-analysisSocial anxiety disorderStriatumStructural MRIVoxel-based morphometry

Identifiers

PMID30140607
PMCPMC6103329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.