Evidence map›Paper›PMID 30140520›Full record

ArticleTurkish journal of anaesthesiology and reanimation2018

Effects of Premedication on Heart Rate Variability at Induction of Anaesthesia: Comparison between Midazolam and Hydroxyzine.

Tomoki Nishiyama

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of anaesthesiology and reanimation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Timing May Influence the Pharmacodynamics of Atropine as Pre-Medication.Turkish journal of anaesthesiology and reanimation · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tomoki NishiyamaDepartment of Anesthesiology, Kamakura Hospital, Kamakura, Japan.ORCID https://orcid.org/0000-0002-1346-3114
Shonan Kamakura General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study was performed to compare the effects of midazolam premedication, which is useful for its anti-anxiety and amnesic effects, with antihistamine hydroxyzine on cardiac sympathetic and parasympathetic activities using heart rate variability (HRV) at induction of anaesthesia.

methodsEighty patients aged 40-60 years, with an American Society of Anaesthesiologists (ASA) physical status of I or II and undergoing general anaesthesia for neck and body surface surgery were randomised equally into midazolam and hydroxyzine groups. As a premedication, midazolam 0.06 mg kg

resultsSystolic blood pressure and heart rate significantly increased after intubation in both groups and the increase was greater in the hydroxyzine group. The high frequency (HF) component decreased significantly in both groups, and no difference was found between the two groups. The low frequency component/HF ratio significantly increased in the hydroxyzine group but did not change in the midazolam group.

conclusionMidazolam but not hydroxyzine premedication inhibited sympathetic activation at induction of anaesthesia.

Indexed as

anaesthesia inductionheart rate variabilityhydroxyzinemidazolamPremedication

Identifiers

PMID30140520
PMCPMC6097857
OpenAlexW2887360493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.