ArticleMolecular cytogenetics2018
Application of chromosomal microarray analysis in products of miscarriage.
Article in Molecular cytogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Etiological diagnosis of miscarriage by combining use of chromosomal microarray analysis and whole-exome sequencing.European journal of medical research · 2025Article
- Clinically significant findings in a decade-long retrospective study of prenatal chromosomal microarray testing.Molecular genetics & genomic medicine · 2024Review
- Experience of copy number variation sequencing applied in spontaneous abortion.BMC medical genomics · 2024Article
- Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis.Annals of medicine · 2023Article
- Fetal congenital gastrointestinal obstruction: prenatal diagnosis of chromosome microarray analysis and pregnancy outcomes.BMC pregnancy and childbirth · 2023Article
- Clinical application of single nucleotide polymorphism microarray analysis in pregnancy loss in Northwest China.Frontiers in genetics · 2023Article
- A chromosomal microarray analysis-based laboratory algorithm for the detection of genetic etiology of early pregnancy loss.Frontiers in genetics · 2023Article
- Article
- Copy Number Variation Analysis of Euploid Pregnancy Loss.Frontiers in genetics · 2022Article
- Copy number variation sequencing combined with quantitative fluorescence polymerase chain reaction in clinical application of pregnancy loss.Journal of assisted reproduction and genetics · 2021Article
- Parental balanced chromosomal rearrangement leading to major genomic imbalance and an autosomal trisomy resulting in consecutive pregnancy loss: a case report.Journal of genetics · 2021Article
- Genetic Testing for Aneuploidy in Patients Who Have Had Multiple Miscarriages: A Review of Current Literature.The application of clinical genetics · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChromosomal abnormality is one of the major cause of spontaneous abortion. Most available guidelines suggest genetic testing after three miscarriages, which has been proved to be difficult to adhere to and somewhat of low cost-effectiveness. As chromosomal microarray analysis has been recommended to be applied on miscarriage products, we managed a retrospective study on our experience investigate the potential impact of this technique on previous guidelines and our present management on miscarried couples and products.
resultsOf the 405 products of conceptions, the overall detection rate of pathogenetic results was 55.3% (224/405), including 7.1% (16/224) copy number changes which could be missed by conventional karyotyping analysis. Of the 222 natural conception samples, abnormal genetic results were found in 126 cases (56.8%). The detection rate in the assistant reproductive treatment group was 53.6% (98/183). No significant difference was found between these two groups (
conclusionsChromosomal microarray testing should be referred to couples at their first miscarriage regardless of the way how they get pregnant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.