ReviewGastroenterology research and practice2018
Current Management of Pancreatic Neuroendocrine Tumors: From Demolitive Surgery to Observation.
Review in Gastroenterology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed.
- Outcomes Following Surgery for Pancreatic Neuro-Endocrine Tumours: A Single-Centre Experience.Clinics and practice · 2025Article
- Investigating machine learning algorithms to classify label-free images of pancreatic neuroendocrine neoplasms.Biophotonics discovery · 2025Article
- Robotic Versus Hand-Assisted Distal Pancreatectomy: A Comparative Single Center Retrospective Study.Journal of clinical medicine · 2025Article
- Tumor and α-SMA-expressing stromal cells in pancreatic neuroendocrine tumors have a distinct RNA profile depending on tumor grade.Molecular oncology · 2025Article
- Comparative Analysis of Complications Following Distal Resections for Neuroendocrine Tumors and Adenocarcinoma: Unveiling the Differences.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Short-term outcomes of laparoscopic and robotic limited resections of pancreatic neuroendocrine tumours of the uncinate process: Report of six cases and review of the literature.Journal of minimal access surgery · 2024Article
- Pancreatic neuroendocrine tumor with solitary splenic metastasis and synchronous renal cell carcinoma: A rare case report.Radiology case reports · 2024Article
- Pancreatic neuroendocrine tumors: Are tumors smaller than 2 cm truly indolent?World journal of gastrointestinal oncology · 2024Article
- Risk factors, prognostic predictors, and nomograms for pancreatic cancer patients with initially diagnosed synchronous liver metastasis.World journal of gastrointestinal oncology · 2023Article
- Utility of fistula risk score in assessing the risk of postoperative pancreatic fistula occurrence and other significant complications after different types of pancreatic neuroendocrine tumor resections.Annals of surgical treatment and research · 2022Article
- EMT Molecular Signatures of Pancreatic Neuroendocrine Neoplasms.International journal of molecular sciences · 2022Article
- Efficacy and safety ofEuropean journal of nuclear medicine and molecular imaging · 2022Article
- Article
- Current update on imaging for pancreatic neuroendocrine neoplasms.World journal of clinical oncology · 2021Review
- CT-derived radiomic features to discriminate histologic characteristics of pancreatic neuroendocrine tumors.La Radiologia medica · 2021Observational
- Endoscopic Ultrasound-Guided Ablation of Focal Pancreatic Lesions: The GRUPUGE Perspective.GE Portuguese journal of gastroenterology · 2020Article
- Multivisceral robotic resection: a glimpse into the future of minimally invasive abdominal surgery.BMJ case reports · 2020Article
- Robotic enucleation of a pancreatic uncinate neuroendocrine tumor - a unique parenchyma-saving strategy for uncinate tumors.Annals of hepato-biliary-pancreatic surgery · 2020Article
- Metastatic insulinoma presenting 14 years after benign tumour resection: a rare case and management dilemma.Endocrinology, diabetes & metabolism case reports · 2020Article
- Treatment Options for Pancreatic Neuroendocrine Tumors.Cancers · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Incidental diagnosis of pancreatic neuroendocrine tumors (PanNETs) greatly increased in the last years. In particular, more frequent diagnosis of small PanNETs leads to many challenging clinical decisions. These tumors are mostly indolent, although a percentage (up to 39%) may reveal an aggressive behaviour despite the small size. Therefore, there is still no unanimity about the best management of tumor smaller than 2 cm. The risks of under/overtreatment should be carefully evaluated with the patient and balanced with the potential morbidities related to surgery. The importance of the Ki-67 index as a prognostic factor is still debated as well. Whenever technically feasible, parenchyma-sparing surgeries lead to the best chance of organ preservation. Lymphadenectomy seems to be another important prognostic issue and, according to recent findings, should be performed in noninsulinoma patients. In the case of enucleation of the lesion, a lymph nodal sampling should always be considered. The relatively recent introduction of minimally invasive techniques (robotic) is a valuable option to deal with these tumors. The current management of PanNETs is analysed throughout the many available published guidelines and evidences with the aim of helping clinicians in the difficult decision-making process.
Identifiers
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Registered trials
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