Evidence map›Paper›PMID 30140120›Full record

ArticleAnnals of neurosciences2018

Alterations in MicroRNA-132/212 Expression Impairs Fear Memory in Goldfish

Subramanian Thangaleela, Vasudevan Shanmugapriya, Murugan Mukilan, Karuppasamy Radhakrishnan, Koilmani Emmanuvel Rajan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Subramanian ThangaleelaBehavioural Neuroscience Laboratory, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Vasudevan ShanmugapriyaBehavioural Neuroscience Laboratory, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Murugan MukilanBehavioural Neuroscience Laboratory, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Karuppasamy RadhakrishnanDepartment of Zoology, Government Arts College, Karur, India.
Koilmani Emmanuvel RajanBehavioural Neuroscience Laboratory, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarlier, we showed that nicotinamide (NAM) treatment impairs spatial memory through the downregulation of CREB-Sirt 1-brain-derived neurotrophic factor ( PURPOSE: In this study, we examine whether NAM treatment alters CREB-regulated genes through -microRNAs.

methodTo test this hypothesis, goldfish (

resultsWe observed that NAM treatment significantly impaired fear memory. Further, the analysis showed that miR-132 level was not altered, but miR-212 level was significantly upregulated after CFC training only in NAM-treated fish. We also found that NAM treatment downregulated IEGs and

conclusionsPresent study suggests that NAM-treatment impaired fear memory and control IEGs,

Indexed as

Brain-derived neurotrophic factorContextual fear conditioningGoldfishImmediate-early genesMicroRNAs-132/212Nicotinamide

Identifiers

PMID30140120
PMCPMC6103369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.