Trial reportPediatric research2018
Reference intervals for reticulocyte hemoglobin content in healthy infants.
Trial report in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- A CBC drawn postnatally from umbilical cord blood can provide valuable diagnostic information for infants admitted to the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Reticulocyte hemoglobin equivalent as a diagnostic parameter of iron deficiency anemia in infants age 1-4 months.Archives of medical science : AMS · 2026Article
- Reference values for reticulocyte haemoglobin equivalent in healthy Chinese children under 5 years and its associations with various blood parameters.BMJ paediatrics open · 2024Article
- Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Prevalence and Implications of Low Reticulocyte-Hemoglobin Levels among Extreme Preterm Neonates: A Single-Center Retrospective Study.Nutrients · 2022Article
- Haemoglobin and red blood cell reference intervals during infancy.Archives of disease in childhood · 2022Article
- Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period.Frontiers in endocrinology · 2022Article
- Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9-11 Months.International journal of general medicine · 2022Article
- Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.Blood cells, molecules & diseases · 2021Article
- Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Diagnostic performance of reticulocyte hemoglobin equivalent in assessing the iron status.Journal of clinical laboratory analysis · 2020Article
- Review
- Review
- Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.Journal of clinical laboratory analysis · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants.
methodsSwedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48-72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He.
resultsReference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1-37.7 pg/L (N = 253) at 48-72 h, 25.6-33.4 pg/L (N = 341) at four months and 24.9-34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) -4.2 pg/L (-6.1 to -2.4) and at 12 months mean difference (95% CI) -3.4 pg/L (-5.0 to -1.8).
conclusionsThis longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.