ArticleScientific reports2018
Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial.The British journal of nutrition · 2024Trial
- Diagnosing and engineering gut microbiomes.EMBO molecular medicine · 2024Review
- Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.bioRxiv : the preprint server for biology · 2024Article
- Utilization of the microbiome in personalized medicine.Nature reviews. Microbiology · 2024Review
- Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.Frontiers in microbiomes · 2024Article
- Effects of OsomeFood Clean Label plant-based meals on the gut microbiome.BMC microbiology · 2023Article
- The microbiome's fiber degradation profile and its relationship with the host diet.BMC biology · 2022Article
- Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions.Advances in nutrition (Bethesda, Md.) · 2022Article
- Microbiome-based therapeutics.Nature reviews. Microbiology · 2022Review
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- Article
- Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome.Microbiome · 2021Article
- Functional heterogeneity in the fermentation capabilities of the healthy human gut microbiota.PloS one · 2021Article
- Metabolic Response ofMicroorganisms · 2020Article
- Prebiotics and Community Composition Influence Gas Production of the Human Gut Microbiota.mBio · 2020Article
- Macroecological dynamics of gut microbiota.Nature microbiology · 2020Article
- Marine Microalgae,Marine drugs · 2020Article
- The Need for Personalized Approaches to Microbiome Modulation.Frontiers in public health · 2020Article
- A Guide to Diet-Microbiome Study Design.Frontiers in nutrition · 2020Review
- Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Dietary interventions to manipulate the human gut microbiome for improved health have received increasing attention. However, their design has been limited by a lack of understanding of the quantitative impact of diet on a host's microbiota. We present a highly controlled diet perturbation experiment in a healthy, human cohort in which individual micronutrients are spiked in against a standardized background. We identify strong and predictable responses of specific microbes across participants consuming prebiotic spike-ins, at the level of both strains and functional genes, suggesting fine-scale resource partitioning in the human gut. No predictable responses to non-prebiotic micronutrients were found. Surprisingly, we did not observe decreases in day-to-day variability of the microbiota compared to a complex, varying diet, and instead found evidence of diet-induced stress and an associated loss of biodiversity. Our data offer insights into the effect of a low complexity diet on the gut microbiome, and suggest that effective personalized dietary interventions will rely on functional, strain-level characterization of a patient's microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.