ArticleCancer discovery2018
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
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Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
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29 citing papers in PubMed, 52 citations in OpenAlex.
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Authors and funding
41 authors at 10 institutions in 4 countries.
Yoshihiro Hayashi *Divisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yue Zhang *State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Asumi Yokota *Divisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Xiaomei YanDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jinqin LiuState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Kwangmin ChoiDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Bing LiState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Goro SashidaInternational Research Center for Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.ORCID 0000-0003-2318-5987
Yanyan PengDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Zefeng XuState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Rui HuangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Lulu ZhangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
George M FreudigerDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jingya WangState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Yunzhu DongDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yile ZhouDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jieyu WangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Lingyun WuDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jiachen BuDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Aili ChenKey Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Xinghui ZhaoDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Xiujuan SunState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Kashish ChetalDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Andre OlssonDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Miki WatanabeDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Lindsey E Romick-RosendaleDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-7252-1193
Hironori HaradaLaboratory of Oncology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Lee-Yung ShihDepartment of Hematology and Oncology, Chang Gung Memorial Hospital-Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan.ORCID 0000-0003-1866-7922
William TseJames Graham Brown Cancer Center, University of Louisville Hospital, Louisville, Kentucky.
James P BridgesDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Michael A CaligiuriThe Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Taosheng HuangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yi ZhengDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
David P WitteDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Qian-Fei WangKey Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Cheng-Kui QuDivision of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia.
Nathan SalomonisDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
H Leighton GrimesDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0001-8162-6758
Stephen D NimerSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Zhijian XiaoState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. Gang.Huang@cchmc.org zjxiao@hotmail.com.
Gang HuangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Gang.Huang@cchmc.org zjxiao@hotmail.com.
Cincinnati Children's Hospital Medical Center · USChinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Institute of Genomics · CNEmory University · USKumamoto University · JPLinkou Chang Gung Memorial Hospital · TWSylvester Comprehensive Cancer Center · USThe Ohio State University · USTokyo University of Pharmacy and Life Sciences · JPUniversity of Louisville Hospital · US
Funding
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4MSPORE Leukemia Tissue BankP50CA140158 · NCI · OHIO STATE UNIVERSITY · PI BLOOMFIELD, CLARA D · 2009 to 2013
$11.2MTargeting p300 and lysine acetylation in AMLR01CA166835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2012 to 2026
$4.6MCincinnati Center for Excellence in Molecular HematologyP30DK090971 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2010 to 2015
$4.0MFunctional Characterization of MLL Gene FusionsR01CA089341 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A · 2002 to 2013
$2.8MRole of the Hypoxia-Inducible Factor-1alpha in Myelodysplastic SyndromesR01DK105014 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HUANG, GANG · 2015 to 2019
$1.8MNCI NIH HHS P50 CA140158NCI NIH HHS R01 CA089341NCI NIH HHS R01 CA166835NIDDK NIH HHS P30 DK090971NIDDK NIH HHS R01 DK105014NIEHS NIH HHS P30 ES006096
Abstract
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic aberrations have been identified in patients with MDS, their clinical features are quite similar. Here, we show that hypoxia-independent activation of hypoxia-inducible factor 1α (HIF1A) signaling is both necessary and sufficient to induce dysplastic and cytopenic MDS phenotypes. The HIF1A transcriptional signature is generally activated in MDS patient bone marrow stem/progenitors. Major MDS-associated mutations (
Indexed as
AnimalsCore Binding Factor Alpha 2 SubunitGene Expression Regulation, NeoplasticHistone-Lysine N-MethyltransferaseHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMetabolomeMiceMice, KnockoutMyelodysplastic SyndromesMyeloid-Lymphoid Leukemia ProteinCore Binding Factor Alpha 2 SubunitHIF1A protein, humanHif1a protein, mouseHistone-Lysine N-MethyltransferaseHypoxia-Inducible Factor 1, alpha SubunitKmt2a protein, mouseMyeloid-Lymphoid Leukemia Protein
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