Evidence map›Paper›PMID 30139740›Full record

ArticleThe Journal of biological chemistry2018

Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit.

Wenping Zhang, Yuqiang Shi, Yanxi Peng, Ling Zhong, Shuang Zhu, Wenbo Zhang, Shao-Jun Tang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Neuropathic pain; what we know and what we should do about it.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wenping ZhangFrom the Departments of Neuroscience and Cell Biology and.
Yuqiang ShiFrom the Departments of Neuroscience and Cell Biology and.
Yanxi Pengthe School of Pharmaceutical Sciences and Laboratory Animal Center of Sun Yat-Sen University, Guangzhou 510275, China.
Ling Zhongthe School of Pharmaceutical Sciences and Laboratory Animal Center of Sun Yat-Sen University, Guangzhou 510275, China.
Shuang ZhuOphthalmology, University of Texas Medical Branch, Galveston, Texas 77555.
Wenbo ZhangFrom the Departments of Neuroscience and Cell Biology and.
Shao-Jun TangFrom the Departments of Neuroscience and Cell Biology and shtang@utmb.edu.ORCID 0000-0002-6076-5481
The University of Texas Medical Branch at Galveston · USSun Yat-sen University · CN

Funding

Wnt signaling in glial activation during HIV-associated chronic pain pathogenesisR01NS079166 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2012 to 2021
$5.5M
Antiretroviral Therapy and Neuroinflammation in the CNSR01NS095747 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M · 2016 to 2020
$2.6M
Pathogenic Role of EPAC1 Signaling in Retinopathy of PrematurityR01EY026629 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ZHANG, WENBO · 2017 to 2021
$2.6M
Interplay of HIV-1 gp120 and opioids in astrocyte activationR01DA036165 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2013 to 2017
$1.9M
NEI NIH HHS R01 EY026629NIDA NIH HHS R01 DA036165NINDS NIH HHS R01 NS079166NINDS NIH HHS R01 NS095747
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is a master regulator of synaptic plasticity in various neural circuits of the mammalian central nervous system. Neuron activity-induced BDNF gene expression is regulated through the Ca

Indexed as

AnimalsAnti-Anxiety AgentsAzepinesBenzamidesbeta CateninBrain-Derived Neurotrophic FactorCapsaicinCerebral CortexEmbryo, MammalianGene Expression RegulationHindlimbIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutANA 12 compoundAnti-Anxiety AgentsAzepinesBdnf protein, mouseBenzamidesbeta CateninBrain-Derived Neurotrophic FactorCapsaicinCTNNB1 protein, mouseGpr177 protein, mouseIntracellular Signaling Peptides and ProteinsReceptors, G-Protein-CoupledReceptors, N-Methyl-D-AspartateWnt3A ProteinWnt3a protein, mousebeta-catenin (B-catenin)brain-derived neurotrophic factor (BDNF)gene expressionneuronpainsynapseWnt signaling

Identifiers

PMID30139740
PMCPMC6177598
OpenAlexW2888731457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.