Evidence map›Paper›PMID 30139607›Full record

ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2018

Segmentation of parotid glands from registered CT and MR images.

Domen Močnik, Bulat Ibragimov, Lei Xing, Primož Strojan, Boštjan Likar, Franjo Pernuš, Tomaž Vrtovec

Abstract readEvaluation Study
In one paragraph

Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Unsupervised deep learning registration model for multimodal brain images.Journal of applied clinical medical physics · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Domen MočnikFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Electronic address: domen.mocnik@fe.uni-lj.si.
Bulat IbragimovDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: bulat@stanford.edu.
Lei XingDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: lei@stanford.edu.
Primož StrojanInstitute of Oncology Ljubljana, Ljubljana, Slovenia. Electronic address: primoz.strojan@onko-i.si.
Boštjan LikarFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Electronic address: bostjan.likar@fe.uni-lj.si.
Franjo PernušFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Electronic address: franjo.pernus@fe.uni-lj.si.
Tomaž VrtovecFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Electronic address: tomaz.vrtovec@fe.uni-lj.si.

Funding

DASSIM-RT and Compressed Sensing-Based Inverse PlanningR01CA176553 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2014 to 2018
$2.4M
Computational Tools for Next Generation Volumetric Cone Beam Computed TomographyR01EB016777 · NIBIB · STANFORD UNIVERSITY · PI XING, LEI · 2013 to 2016
$2.1M
NCI NIH HHS R01 CA176553NIBIB NIH HHS R01 EB016777
6 · The paper itself

Abstract

purposeTo develop an automatic multimodal method for segmentation of parotid glands (PGs) from pre-registered computed tomography (CT) and magnetic resonance (MR) images and compare its results to the results of an existing state-of-the-art algorithm that segments PGs from CT images only.

methodsMagnetic resonance images of head and neck were registered to the accompanying CT images using two different state-of-the-art registration procedures. The reference domains of registered image pairs were divided on the complementary PG regions and backgrounds according to the manual delineation of PGs on CT images, provided by a physician. Patches of intensity values from both image modalities, centered around randomly sampled voxels from the reference domain, served as positive or negative samples in the training of the convolutional neural network (CNN) classifier. The trained CNN accepted a previously unseen (registered) image pair and classified its voxels according to the resemblance of its patches to the patches used for training. The final segmentation was refined using a graph-cut algorithm, followed by the dilate-erode operations.

resultsUsing the same image dataset, segmentation of PGs was performed using the proposed multimodal algorithm and an existing monomodal algorithm, which segments PGs from CT images only. The mean value of the achieved Dice overlapping coefficient for the proposed algorithm was 78.8%, while the corresponding mean value for the monomodal algorithm was 76.5%.

conclusionsAutomatic PG segmentation on the planning CT image can be augmented with the MR image modality, leading to an improved RT planning of head and neck cancer.

Indexed as

AdolescentAdultAgedAged, 80 and overAlgorithmsChildFemaleHeadHead and Neck NeoplasmsHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingNeckImage registrationImage segmentationParotid glandsXerostomia

Identifiers

PMID30139607
PMCPMC6110103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.