ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2018
Natural history of prostatic lesions on serial multiparametric magnetic resonance imaging.
Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The natural history of prostate cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Review
- Biparametric MRI in prostate cancer during active surveillance: is it safe?European radiology · 2024Review
- Stability of Multi-Parametric Prostate MRI Radiomic Features to Variations in Segmentation.Journal of personalized medicine · 2023Article
- A prospective study of cancer detection rates following early repeat imaging and biopsy of PI-RADS 4 and 5 regions of interest exhibiting no clinically significant prostate cancer on prior biopsy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Bridging the gap between prostate radiology and pathology through machine learning.Medical physics · 2022Article
- Alternatives for MRI in Prostate Cancer Diagnostics-Review of Current Ultrasound-Based Techniques.Cancers · 2022Review
- Five-year Outcomes of Magnetic Resonance Imaging-based Active Surveillance for Prostate Cancer: A Large Cohort Study.European urology · 2020Article
- Multiparametric MRI for prostate cancer diagnosis: current status and future directions.Nature reviews. Urology · 2020Review
- Magnetic resonance imaging diagnosis of prostate cancer: promise and caution.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
- Early Second Round Targeted Biopsy of PI-RADS Score 3 or 4 in 256 Men With Persistent Suspicion of Prostate Cancer.In vivo (Athens, Greece)Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe natural history of prostatic lesions identified on multiparametric magnetic resonance imaging (mpMRI) is largely unknown. We aimed to describe changes observed over time on serial MRI.
methodsAll patients with ≥2 MRI studies between 2008 and 2015 at our institution were identified. MRI progression was defined as an increase in Prostate Imaging Reporting and Data System (PI-RADS; version 2) or size of existing lesions, or the appearance of a new lesion PIRADS ≥4. Patients on active surveillance (AS) were analyzed for correlation of MRI progression to biopsy reclassification.
resultsA total of 83 patients (54 on AS and 29 for diagnostic purposes) underwent serial MRI, with a mean interval of 1.9 years between scans. At baseline, 115 lesions (66 index, 49 non-index) were identified. Index lesions were more likely than non-index lesions to increase in size ≥2 mm (36.2 vs. 7.3 %; p=0.002). Overall progression was more likely to be seen among the index cohort (34.8 vs. 7.6%; p<0.001). New lesions with PI-RADS ≥4 were seen on second imaging in 13 (16.5%) men, and became the index lesion in 29 cases (34.9%). Eighteen men on AS showed evidence of MRI progression (five with new lesions, 13 with progression of a previous lesion). Biopsy reclassification was present in three men (16.7%) with and seven men without MRI progression (19.4%).
conclusionsOverall changes in size and PI-RADS scores of index lesions on MRI were small. New lesions were common, but usually did not alter management.
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